Targeting HSP70 for Cancer Therapy

被引：45

作者：

Galluzzi, Lorenzo ^{[1
,2
]}

Giordanetto, Fabrizio ^{[3
]}

Kroemer, Guido ^{[1
,2
]}

机构：

[1] Inst Gustave Roussy, INSERM, U848, F-94805 Villejuif, France

[2] Univ Paris 11, F-94270 Le Kremlin Bicetre, France

[3] AstraZeneca R&D, Lead Generat, SE-43183 Molndal, Sweden

来源：

MOLECULAR CELL | 2009年 / 36卷 / 02期

关键词：

MITOCHONDRIAL-MEMBRANE PERMEABILIZATION; SMALL-MOLECULE INHIBITOR; HEAT-SHOCK-PROTEIN-70;

D O I：

10.1016/j.molcel.2009.10.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a recent issue of Molecular Cell, Leu et al. (2009) demonstrate that a chemical inhibitor of HSP70 exerts prominent tumor-selective cytotoxic effects, thereby lending further support to the notion that non-oncogene addiction constitutes a promising target for anticancer therapy.

引用

页码：176 / 177

页数：2

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