Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome

被引：21
作者：
Goodarzi, Mark O.
Antoine, Heath J.
Pall, Marita
Cui, Jinrui
Guo, Xiuqing
Azziz, Ricardo
机构：
[1] Cedars Sinai Med Ctr, Dept Obstet & Gynecol, Los Angeles, CA 90048 USA
[2] Cedars Sinai Med Ctr, Dept Med, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA
[3] Cedars Sinai Med Ctr, Inst Med Genet, Los Angeles, CA 90048 USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA USA
[5] Univ Calif Los Angeles, David Geffen Sch Med, Dept Obstet & Gynecol, Los Angeles, CA USA
来源：
FERTILITY AND STERILITY | 2007年 / 87卷 / 06期
关键词：
D O I：
10.1016/j.fertnstert.2006.11.041
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
In this study of 352 women with polycystic ovary syndrome (PCOS) and 289 control women, haplotypes spanning the gene for glycogen synthase kinase 3 beta (GSK3B) were constructed on the basis of nine single-nucleotide polymorphisms in white and black subjects separately. In each racial group, we observed that a specific, although different, GSK3B haplotype was associated with increased frequency of PCOS, suggesting that GSK3 beta contributes to the pathophysiology and inherited basis of PCOS.
引用
收藏
页码：1473 / 1476
页数：4
相关论文
共 28 条
  • [1] A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain
    Asunción, M
    Calvo, RM
    San Millán, JL
    Sancho, J
    Avila, S
    Escobar-Morreale, HF
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (07) : 2434 - 2438
  • [2] The prevalence and features of the polycystic ovary syndrome in an unselected population
    Azziz, R
    Woods, KS
    Reyna, R
    Key, TJ
    Knochenhauer, ES
    Yildiz, BO
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (06) : 2745 - 2749
  • [3] Haploview: analysis and visualization of LD and haplotype maps
    Barrett, JC
    Fry, B
    Maller, J
    Daly, MJ
    [J]. BIOINFORMATICS, 2005, 21 (02) : 263 - 265
  • [4] Selective insulin resistance in the polycystic ovary syndrome
    Book, CB
    Dunaif, A
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (09) : 3110 - 3116
  • [5] Use of fasting blood to assess the prevalence of insulin resistance in women with polycystic ovary syndrome
    Carmina, E
    Lobo, RA
    [J]. FERTILITY AND STERILITY, 2004, 82 (03) : 661 - 665
  • [6] Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment
    DeUgarte, CM
    Bartolucci, AA
    Azziz, R
    [J]. FERTILITY AND STERILITY, 2005, 83 (05) : 1454 - 1460
  • [7] A survey of the polycystic ovary syndrome in the Greek island of Lesbos: Hormonal and metabolic profile
    Diamanti-Kandarakis, E
    Kouli, CR
    Bergiele, AT
    Filandra, FA
    Tsianateli, TC
    Spina, GG
    Zapanti, ED
    Bartzis, MI
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1999, 84 (11) : 4006 - 4011
  • [8] PROFOUND PERIPHERAL INSULIN RESISTANCE, INDEPENDENT OF OBESITY, IN POLYCYSTIC OVARY SYNDROME
    DUNAIF, A
    SEGAL, KR
    FUTTERWEIT, W
    DOBRJANSKY, A
    [J]. DIABETES, 1989, 38 (09) : 1165 - 1174
  • [9] Glycogen synthase kinase 3: an emerging therapeutic target
    Eldar-Finkelman, H
    [J]. TRENDS IN MOLECULAR MEDICINE, 2002, 8 (03) : 126 - 132
  • [10] The molecular-genetic basis of functional hyperandrogenism and the polycystic ovary syndrome
    Escobar-Morreale, HF
    Luque-Ramírez, M
    San Millán, JL
    [J]. ENDOCRINE REVIEWS, 2005, 26 (02) : 251 - 282
123