Intestinal-borne dermatoses significantly improved by oral application of Escherichia coli Nissle 1917
被引:27
作者:
Manzhalii, Elina
论文数: 0引用数: 0
h-index: 0
机构:
Bogomolets Natl Med Univ, Dept Propedeut Internal Med 2, UA-02097 City Kiev, UkraineBogomolets Natl Med Univ, Dept Propedeut Internal Med 2, UA-02097 City Kiev, Ukraine
Manzhalii, Elina
[1
]
论文数: 引用数:
h-index:
机构:
Hornuss, Daniel
[2
]
论文数: 引用数:
h-index:
机构:
Stremmel, Wolfgang
[2
]
机构:
[1] Bogomolets Natl Med Univ, Dept Propedeut Internal Med 2, UA-02097 City Kiev, Ukraine
Intestinal-borne dermatoses;
Escherichia coli Nissle 1917;
Immunological response;
IgA;
Interleukin-8;
Interferon-alpha;
Gut microbiota;
INFLAMMATORY-BOWEL-DISEASE;
EPITHELIAL-CELLS;
GUT MICROBIOTA;
STRAIN NISSLE-1917;
PROBIOTIC BACTERIUM;
HUMAN HEALTH;
PATHOGENS;
INVASION;
LINKING;
D O I:
10.3748/wjg.v22.i23.5415
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
AIM: To evaluate the effect of oral Escherichia coli (E. coli) Nissle application on the outcome of intestinal-borne dermatoses. METHODS: In a randomized, controlled, non-blinded prospective clinical trial 82 patients with intestinal-borne facial dermatoses characterized by an erythematous papular-pustular rash were screened. At the initiation visit 37 patients entered the experimental arm and 20 patients constituted the control arm. All 57 patients were treated with a vegetarian diet and conventional topical therapy of the dermatoses with ointments containing tetracycline, steroids and retinoids. In the experimental arm patients received a one month therapy with oral E. coli Nissle at a maintenance dose of 2 capsules daily. The experimental group was compared to a non-treatment group only receiving the diet and topical therapy. The primary outcome parameter was improvement of the dermatoses, secondary parameters included life quality and adverse events. In addition the immunological reaction profile (IgA, interleucin-8 and interferon-alpha) was determined. Furthermore the changes of stool consistency and the microbiota composition over the time of intervention were recorded. RESULTS: Eighty-nine percent of the patients with acne, papular-pustular rosacea and seborrhoic dermatitis responded to E. coli Nissle therapy with significant amelioration or complete recovery in contrast to 56% in the control arm (P < 0.01). Accordingly, in the E. coli Nissle treated patients life quality improved significantly (P < 0.01), and adverse events were not recorded. The clinical improvement was associated with a significant increase of IgA levels to normal values in serum as well as suppression of the proinflammatory cytokine IL-8 (P < 0.01 for both parameters). In the E. coli Nissle treated group a shift towards a protective microbiota with predominance of bifidobacteria and lactobacteria (> 10(7) CFU/g stool) was observed in 79% and 63% of the patients, respectively (P < 0.01), compared to no change in the control group without E. coli Nissle. Moreover, the detection rate of a pathogenic flora dropped from 73% to 14 % of the patients in the experimental arm (P < 0.01) with no significant change in the control arm (accounting 80% before and 70% after the observation period, P > 0.05). Accordingly, stool consistency, color and smell normalized in the E. coli Nissle treated patients. CONCLUSION: E. coli Nissle protects the mucus barrier by overgrowth of a favorable gut microbiota with less immunoreactive potential which finally leads to clinical improvement of intestinal borne dermatoses.
机构:Univ British Columbia, Michael Smith Labs, Dept Microbiol & Immunol, 301-2185 East Mall, Vancouver, BC V6T 1Z4, Canada
Sekirov, Inna
;
Russell, Shannon L.
论文数: 0引用数: 0
h-index: 0
机构:Univ British Columbia, Michael Smith Labs, Dept Microbiol & Immunol, 301-2185 East Mall, Vancouver, BC V6T 1Z4, Canada
Russell, Shannon L.
;
Antunes, L. Caetano M.
论文数: 0引用数: 0
h-index: 0
机构:Univ British Columbia, Michael Smith Labs, Dept Microbiol & Immunol, 301-2185 East Mall, Vancouver, BC V6T 1Z4, Canada
Antunes, L. Caetano M.
;
Finlay, B. Brett
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Michael Smith Labs, Dept Microbiol & Immunol, 301-2185 East Mall, Vancouver, BC V6T 1Z4, CanadaUniv British Columbia, Michael Smith Labs, Dept Microbiol & Immunol, 301-2185 East Mall, Vancouver, BC V6T 1Z4, Canada
机构:
Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Wu, Gary D.
;
Chen, Jun
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Chen, Jun
;
Hoffmann, Christian
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA
Univ Fed Goias, Inst Ciencias Biol, BR-74001970 Goiania, Go, BrazilUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Hoffmann, Christian
;
Bittinger, Kyle
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Bittinger, Kyle
;
Chen, Ying-Yu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Chen, Ying-Yu
;
Keilbaugh, Sue A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Keilbaugh, Sue A.
;
Bewtra, Meenakshi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Bewtra, Meenakshi
;
Knights, Dan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Knights, Dan
;
Walters, William A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Walters, William A.
;
Knight, Rob
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Knight, Rob
;
Sinha, Rohini
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Sinha, Rohini
;
Gilroy, Erin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Gilroy, Erin
;
Gupta, Kernika
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Gastroenterol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Gupta, Kernika
;
Baldassano, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Gastroenterol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Baldassano, Robert
;
Nessel, Lisa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Nessel, Lisa
;
Li, Hongzhe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Li, Hongzhe
;
Bushman, Frederic D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Bushman, Frederic D.
;
Lewis, James D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
机构:Univ British Columbia, Michael Smith Labs, Dept Microbiol & Immunol, 301-2185 East Mall, Vancouver, BC V6T 1Z4, Canada
Sekirov, Inna
;
Russell, Shannon L.
论文数: 0引用数: 0
h-index: 0
机构:Univ British Columbia, Michael Smith Labs, Dept Microbiol & Immunol, 301-2185 East Mall, Vancouver, BC V6T 1Z4, Canada
Russell, Shannon L.
;
Antunes, L. Caetano M.
论文数: 0引用数: 0
h-index: 0
机构:Univ British Columbia, Michael Smith Labs, Dept Microbiol & Immunol, 301-2185 East Mall, Vancouver, BC V6T 1Z4, Canada
Antunes, L. Caetano M.
;
Finlay, B. Brett
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Michael Smith Labs, Dept Microbiol & Immunol, 301-2185 East Mall, Vancouver, BC V6T 1Z4, CanadaUniv British Columbia, Michael Smith Labs, Dept Microbiol & Immunol, 301-2185 East Mall, Vancouver, BC V6T 1Z4, Canada
机构:
Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Wu, Gary D.
;
Chen, Jun
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Chen, Jun
;
Hoffmann, Christian
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA 19104 USA
Univ Fed Goias, Inst Ciencias Biol, BR-74001970 Goiania, Go, BrazilUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Hoffmann, Christian
;
Bittinger, Kyle
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Bittinger, Kyle
;
Chen, Ying-Yu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Chen, Ying-Yu
;
Keilbaugh, Sue A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Keilbaugh, Sue A.
;
Bewtra, Meenakshi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Bewtra, Meenakshi
;
Knights, Dan
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Comp Sci, Boulder, CO 80309 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Knights, Dan
;
Walters, William A.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Walters, William A.
;
Knight, Rob
论文数: 0引用数: 0
h-index: 0
机构:
Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA
Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Knight, Rob
;
Sinha, Rohini
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Sinha, Rohini
;
Gilroy, Erin
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Gilroy, Erin
;
Gupta, Kernika
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Gastroenterol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Gupta, Kernika
;
Baldassano, Robert
论文数: 0引用数: 0
h-index: 0
机构:
Childrens Hosp Philadelphia, Div Gastroenterol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Baldassano, Robert
;
Nessel, Lisa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Nessel, Lisa
;
Li, Hongzhe
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Li, Hongzhe
;
Bushman, Frederic D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Dept Microbiol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Bushman, Frederic D.
;
Lewis, James D.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA
Univ Penn, Perelman Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USAUniv Penn, Perelman Sch Med, Div Gastroenterol, Philadelphia, PA 19104 USA