Surface modification of microfluidic channels by UV-mediated graft polymerization of non-fouling and 'smart' polymers

被引：59

作者：

Ebara, Mitsuhiro ^{[1
]}

Hoffman, John M. ^{[1
]}

Stayton, Patrick S. ^{[1
]}

Hoffman, Allan S. ^{[1
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

来源：

RADIATION PHYSICS AND CHEMISTRY | 2007年 / 76卷 / 8-9期

基金：

美国国家卫生研究院;

关键词：

smart polymers; N-isopropylacrylamide; nanobeads; UV-graft polymerization; microfluidics;

D O I：

10.1016/j.radphyschem.2007.02.072

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Microfluidic channels prepared from polydimethylsiloxane (PDMS) have been modified by UV-mediated graft polymerization of temperature-responsive polymers (poly[N-isopropyl acrylamide] or pNIPAAm), temperature- and pH-responsive copolymers (P[NIPAAm-co-acrylic acid (AAc)]), and a non-fouling hydrogel (polyethyleneglycol diacrylate, or PEGDA). This was done by presorbing a photosensitizer (PS) within the PDMS channel surface regions, contacting the different monomer solutions with the PS-containing surface under nitrogen, and irradiating with UV. The pNIPAAm-grafted surface was hydrophilic below its lower critical solution temperature (LCST), resisting non-specific adsorption, while it was hydrophobic above its LCST, now binding pNIPAAm-coated nanoparticles. Combined temperature- and pH-responsive surfaces were also prepared by UV radiation grafting a monomer mixture of pNIPAAm with AAc. The surfaces have been characterized by advancing water contact angle measurements. These smart microfluidic channels should be useful for many applications such as affinity separations and diagnostic assays. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1409 / 1413

页数：5

共 24 条

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