Flavonoids from Milletia leucantha and Their Cytotoxicity

被引：1

作者：

Sriphana, Uraiwan ^{[1
]}

Yenjai, Chavi ^{[2
]}

Tungnoi, Siriporn ^{[1
]}

Srirapa, Jongjai ^{[1
]}

Junsongduang, Auemporn ^{[1
]}

机构：

[1] Roi Et Rajabhat Univ, Fac Liberal Arts & Sci, Dept Sci & Technol, Roi Et 45120, Thailand

[2] Khon Kaen Univ, Fac Sci, Ctr Excellence Innovat Chem, Dept Chem,Nat Prod Res Unit, Khon Kaen 40002, Thailand

来源：

NATURAL PRODUCT COMMUNICATIONS | 2018年 / 13卷 / 08期

关键词：

Millettia leucantha; Cytotoxicity; Chalcone; Flavone; Flavonol; PONGAMIA-PINNATA; CONSTITUENTS; ISOFLAVONES; BARK;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two known chalcones (1-2), five known flavonol derivatives (3 and 5-8) and one flavone (4) were isolated for the first time from fruits of Millettia leucantha Kurz. In addition, 5 was found for the first time from this genus. Their structures were elucidated on the basis of IR, MS, 1D and 2D NMR techniques. Chalcone 1 exhibited moderate cytotoxicity against the MCF-7 cell line with an IC50 value of 50.93 mu M, whereas this compound showed inactive cytotoxicity against Vero cells. Compound 2 exhibited cytotoxicity against the KB, NCl-H187 and Vero cell lines with IC50 values of 63.64, 114.44 and 28.44 mu M, respectively. Compound 8 only showed cytotoxic activity against the KB cell line with an IC50 value of 110.23 mu M.

引用

页码：961 / 962

页数：2

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