Therapeutic implications and clinical manifestations of thymoquinone

被引：31

作者：

Alam, Manzar ^{[1
]}

Hasan, Gulam Mustafa ^{[2
]}

Ansari, Md Meraj ^{[3
]}

Sharma, Rishi ^{[4
]}

Yadav, Dharmendra Kumar ^{[5
]}

Hassan, Md Imtaiyaz ^{[1
]}

机构：

[1] Jamia Millia Islamia, Ctr Interdisciplinary Res Basic Sci, New Delhi 110025, India

[2] Prince Sattam Bin Abdulaziz Univ, Coll Med, Dept Biochem, POB 173, Al Kharj 11942, Saudi Arabia

[3] Natl Inst Pharmaceut Educ & Res, Ctr Pharmaceut Nanotechnol, Dept Pharmaceut, SAS Nagar, Mohali 160062, Punjab, India

[4] All India Inst Med Sci, Dept Forens Med & Toxicol, Rishikesh 249203, Uttaranchal, India

[5] Gachon Univ Med & Sci, Coll Pharm, Incheon City 21924, South Korea

来源：

PHYTOCHEMISTRY | 2022年 / 200卷

关键词：

Thymoquinone; Apoptosis; Anti-cancer; Anti-oxidant; Anti-inflammatory; Cancer therapy; Signaling pathways; SQUAMOUS-CELL CARCINOMA; NIGELLA-SATIVA OIL; NF-KAPPA-B; EPITHELIAL-MESENCHYMAL TRANSITION; PROSTATE-CANCER CELLS; HUMAN HEPATIC CARCINOMA; OXIDATIVE STRESS; INHIBITS PROLIFERATION; ANTITUMOR-ACTIVITY; BREAST-CANCER;

D O I：

10.1016/j.phytochem.2022.113213

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thymoquinone (TQ), a natural phytochemical predominantly found in Nigella sativa, has been investigated for its numerous health benefits. TQ showed anti-cancer, anti-oxidant, and anti-inflammatory properties, validated in various disease models. The anti-cancer potential of TQ is goverened by anti-proliferation, cell cycle arrest, apoptosis induction, ROS production, anti-metastasis and anti-angiogenesis, inhibition of cell migration and invasion action. Additionally, TQ exhibited antitumor activity via the modulation of multiple pathways and molecular targets, including Akt, ERK1/2, STAT3, and NF-kappa B. The present review highlighted the anticancer potential of TQ . We summarize the anti-cancer, anti-oxidant, and anti-inflammatory properties of TQ, focusing on its molecular targets and its promising action in cancer therapy. We further described the molecular mechanisms by which TQ prevents signaling pathways that mediate cancer progression, invasion, and metastasis.

引用

页数：15

共 275 条

[41] Rosmarinic Acid Exhibits Anticancer Effects via MARK4 Inhibition [J].

Anwar, Saleha ;

Shamsi, Anas ;

Shahbaaz, Mohd ;

Queen, Aarfa ;

Khan, Parvez ;

Hasan, Gulam Mustafa ;

Islam, Asimul ;

Alajmi, Mohamed F. ;

Hussain, Afzal ;

Ahmad, Faizan ;

Hassan, Md Imtaiyaz .

SCIENTIFIC REPORTS, 2020, 10 (01)

[42] Structural and biochemical investigation of MARK4 inhibitory potential of cholic acid: Towards therapeutic implications in neurodegenerative diseases [J].

Anwar, Saleha ;

Shamsi, Anas ;

Kar, Rajiv K. ;

Queen, Aarfa ;

Islam, Asimul ;

Ahmad, Faizan ;

Hassan, Md Imtaiyaz .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 161 :596-604

[43] Discovery of Hordenine as a Potential Inhibitor of Pyruvate Dehydrogenase Kinase 3: Implication in Lung Cancer Therapy [J].

Anwar, Saleha ;

Mohammad, Taj ;

Shamsi, Anas ;

Queen, Aarfa ;

Parveen, Shahnaz ;

Luqman, Suaib ;

Hasan, Gulam Mustafa ;

Alamry, Khalid A. ;

Azum, Naved ;

Asiri, Abdullah M. ;

Hassan, Md Imtaiyaz .

BIOMEDICINES, 2020, 8 (05)

[44] Thymoquinone up-regulates PTEN expression and induces apoptosis in doxorubicin-resistant human breast cancer cells [J].

Arafa, El-Shaimaa A. ;

Zhu, Qianzheng ;

Shah, Zubair I. ;

Wani, Gulzar ;

Barakat, Bassant M. ;

Racoma, Ira ;

El-Mandy, Mohamed A. ;

Wani, Altar A. .

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2011, 706 (1-2) :28-35

[45] Thymoquinone attenuates rheumatoid arthritis by downregulating TLR2, TLR4, TNF-α, IL-1, and NFκB expression levels [J].

Arjumand, Sabeen ;

Shahzad, Muhammad ;

Shabbir, Arham ;

Yousaf, Muhammad Zubair .

BIOMEDICINE & PHARMACOTHERAPY, 2019, 111 :958-963

[46]

Asfour W., 2013, Pharmacology and Pharmacy, V4, P7

[47] Thymoquinone suppression of the human hepatocellular carcinoma cell growth involves inhibition of IL-8 expression, elevated levels of TRAIL receptors, oxidative stress and apoptosis [J].

Ashour, Abdelkader E. ;

Abd-Allah, Adel R. ;

Korashy, Hesham M. ;

Attia, Sabry M. ;

Alzahrani, Abdelrahman Z. ;

Saquib, Quaiser ;

Bakheet, Saleh A. ;

Abdel-Hamied, Hala E. ;

Jamal, Shazia ;

Rishi, Arun K. .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2014, 389 (1-2) :85-98

[48] Implications of the second wave of COVID-19 in India [J].

Asrani, Purva ;

Eapen, Mathew Suji ;

Hassan, Md Imtaiyaz ;

Sohal, Sukhwinder Singh .

LANCET RESPIRATORY MEDICINE, 2021, 9 (09) :E91-E92

[49] SARS-CoV-2 mediated lung inflammatory responses in host: targeting the cytokine storm for therapeutic interventions [J].

Asrani, Purva ;

Hassan, Md Imtaiyaz .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2021, 476 (02) :675-687

[50] Natural products in drug discovery: advances and opportunities [J].

Atanasov, Atanas G. ;

Zotchev, Sergey B. ;

Dirsch, Verena M. ;

Supuran, Claudiu T. .

NATURE REVIEWS DRUG DISCOVERY, 2021, 20 (03) :200-216

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