Inhibitors of c-Jun N-Terminal Kinases: An Update

被引：79

作者：

Koch, Pierre ^{[1
]}

Gehringer, Matthias ^{[1
]}

Laufer, Stefan A. ^{[1
]}

机构：

[1] Univ Tubingen, Inst Pharmaceut Sci, Dept Pharmaceut & Med Chem, D-72076 Tubingen, Germany

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 58卷 / 01期

关键词：

SMALL-MOLECULE INHIBITORS; SELECTIVE JNK INHIBITORS; LEUCINE-ZIPPER KINASE; INDUCED CELL-DEATH; PROTEIN-KINASE; BIOLOGICAL EVALUATION; THERAPEUTIC TARGET; PEPTIDE INHIBITOR; STRUCTURAL BASIS; DRUG DISCOVERY;

D O I：

10.1021/jm501212r

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the pathogenesis of various diseases. Recent advances in the development of novel inhibitors of JNKs will be reviewed. Significant progress in the design of JNK inhibitors displaying selectivity versus other kinases has been achieved within the past 4 years. However, the development of isoform selective JNK inhibitors is still an open task.

引用

页码：72 / 95

页数：24

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