How does the hydrophobic content of methacrylate ABA triblock copolymers affect polymersome formation?

被引：5

作者：

Zhang, Xinmo ^{[1
]}

Contini, Claudia ^{[2
]}

Constantinou, Anna P. ^{[2
]}

Doutch, James J. ^{[3
]}

Georgiou, Theoni K. ^{[1
]}

机构：

[1] Royal Sch Mines, Dept Mat, Exhibit Rd, London SW7 2AZ, England

[2] Imperial Coll London, Mol Sci Res Hub, Dept Chem, 82 Wood Lane, London W12 0BZ, England

[3] STFC, Rutherford Appleton Lab, ISIS Neutron & Muon Source, Didcot, Oxon, England

来源：

JOURNAL OF POLYMER SCIENCE | 2021年 / 59卷 / 15期

关键词：

2-(diethylamino)ethyl methacrylate; ABA triblock copolymers; poly(ethylene glycol) methyl methacrylate; polymersomes; self-assembly; GROUP-TRANSFER POLYMERIZATION; THERMORESPONSIVE GELS; RESPONSIVE POLYMERSOMES; GLYCOL) METHACRYLATE; AMPHIPHILIC DIBLOCK; VESICLES; PH; ARCHITECTURE; MICELLES; NANOREACTORS;

D O I：

10.1002/pol.20210371

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Polymersomes are exciting self-assembled structures with great potential in pharmaceutical applications. A systematic investigation of a novel series of methacrylate-based polymersomes is reported in this study. Five well-defined ABA triblock copolymers with A being based on tri(ethylene glycol) methyl methacrylate and B being based on 2-(diethylamino)ethyl methacrylate (DMAEMA) were synthesized using a living polymerization method. The effect of the composition of the ABA triblock copolymers on the thickness of the hydrophobic membrane of the polymersomes and the release of a model drug is demonstrated.

引用

页码：1724 / 1731

页数：8

共 9 条

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[2] Atomic force microscopy study of self-assembly behaviors of hydrophobic poly(n-butyl methacrylate)-block-polydimethylsiloxane-block-poly(n-butyl methacrylate) ABA triblock copolymers
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[8] How does Micro- and Macro-Phase Separation of Block Copolymers Affect the Formation of Integral Asymmetric Isoporous Membranes? A Review on Effective Factors
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[9] Modifying the Hydrophilic-Hydrophobic Interface of PEG-b-PCL To Increase Micelle Stability: Preparation of PEG-b-PBO-b-PCL Triblock Copolymers, Micelle Formation, and Hydrolysis Kinetics
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