Acute high-frequency rTMS of the left dorsolateral prefrontal cortex and attentional control in healthy young men

被引：43

作者：

Hwang, Ji Hee ^{[2
]}

Kim, Sang Hee ^{[1
]}

Park, Chang Soo ^{[2
]}

Bang, Seong Ae ^{[2
]}

Kim, Sang Eun ^{[2
]}

机构：

[1] Korea Univ, Dept Brain & Cognit Engn, Seoul 136713, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Nucl Med, Bundang Hosp, Seoul, South Korea

来源：

BRAIN RESEARCH | 2010年 / 1329卷

基金：

新加坡国家研究基金会;

关键词：

rTMS; Dorsolateral prefrontal cortex; Attentional control; Conners' CPT; TRANSCRANIAL MAGNETIC STIMULATION; ANTERIOR CINGULATE CORTEX; PARKINSONS-DISEASE; STRIATAL DOPAMINE; PARIETAL CORTEX; MOTOR CORTEX; PERFORMANCE; DEPRESSION; RELEASE; TIME;

D O I：

10.1016/j.brainres.2010.03.013

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies have shown that high-frequency repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex induces neuromodulation in prefrontal and striatal regions. We hypothesized that high-frequency rTMS over the dorsolateral prefrontal cortex would influence attentional control, which has been associated with neural activity in the same region. Seventeen healthy young men volunteered to participate in a sham-controlled rTMS study. Participants received both rTMS and sham stimulation on separate days and the Conners' continuous performance test was used to assess response inhibition and attentional vigilance. Results indicated that participants showed fewer commission errors during trials after rTMS as compared with sham stimulation, at longer interstimulus intervals (ISIS), which suggests that high-frequency rTMS may have the potential to improve response inhibition. This finding contributes to the understanding of the relationship between the dorsolateral prefrontal cortex and attentional control and suggests possible therapeutic applications for high-frequency rTMS. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：152 / 158

页数：7

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