N-Glycomic Signature of Stage II Colorectal Cancer and Its Association With the Tumor Microenvironment

被引：49

作者：

Boyaval, Fanny ^{[1
,2
]}

van Zeijl, Rene ^{[2
]}

Dalebout, Hans ^{[2
]}

Holst, Stephanie ^{[2
]}

van Pelt, Gabi ^{[3
]}

Farina-Sarasqueta, Arantza ^{[1
,4
]}

Mesker, Wilma ^{[3
]}

Tollenaar, Rob ^{[3
]}

Morreau, Hans ^{[1
]}

Wuhrer, Manfred ^{[2
]}

Heijs, Bram ^{[2
]}

机构：

[1] Leiden Univ, Dept Pathol, Med Ctr, Leiden, Netherlands

[2] Leiden Univ, Ctr Prote & Metabol, Med Ctr, Leiden, Netherlands

[3] Leiden Univ, Dept Surg, Med Ctr, Leiden, Netherlands

[4] Univ Amsterdam, Dept Pathol, Med Ctr, Amsterdam, Netherlands

来源：

MOLECULAR & CELLULAR PROTEOMICS | 2021年 / 20卷

关键词：

IMAGING MASS-SPECTROMETRY; SIALIC-ACID RESIDUES; ACETYLGLUCOSAMINYLTRANSFERASE-III; GLYCAN ANALYSIS; GLYCOSYLATION; EXPRESSION; TOOL; GLYCOPROTEINS; SIALYLATION; BIOMARKERS;

D O I：

10.1074/mcp.RA120.002215

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The choice for adjuvant chemotherapy in stage II colorectal cancer is controversial as many patients are cured by surgery alone and it is difficult to identify patients with high risk of recurrence of the disease. There is a need for better stratification of this group of patients. Mass spectrometry imaging could identify patients at risk. We report here the N-glycosylation signatures of the different cell populations in a group of stage II colorectal cancer tissue samples. The cancer cells, compared with normal epithelial cells, have increased levels of sialylation and high-mannose glycans, as well as decreased levels of fucosylation and highly branched N-glycans. When looking at the interface between cancer and its microenvironment, it seems that the cancer N-glycosylation signature spreads into the surrounding stroma at the invasive front of the tumor. This finding was more outspoken in patients with a worse outcome within this sample group.

引用

页数：10

共 59 条

[11] The Interplay between Colon Cancer Cells and Tumour-Associated Stromal Cells Impacts the Biological Clock and Enhances Malignant Phenotypes [J].

Fuhr, Luise ;

Abreu, Monica ;

Carbone, Annalucia ;

El-Athman, Rukeia ;

Bianchi, Fabrizio ;

Laukkanen, Mikko O. ;

Mazzoccoli, Gianluigi ;

Relogio, Angela .

CANCERS, 2019, 11 (07)

[12] Associated expression of α2,3sialylated type 2 chain structures with lymph node metastasis in distal colorectal cancer [J].

Fukasawa, Takaharu ;

Asao, Takayuki ;

Yamauchi, Hayato ;

Ide, Munenori ;

Tabe, Yuichi ;

Fujii, Takaaki ;

Yamaguchi, Satoru ;

Tsutsumi, Soichi ;

Yazawa, Shin ;

Kuwano, Hiroyuki .

SURGERY TODAY, 2013, 43 (02) :155-162

[13] Post-translational Glycoprotein Modifications Regulate Colon Cancer Stem Cells and Colon Adenoma Progression in Apcmin/+ Mice through Altered Wnt Receptor Signaling [J].

Guo, Huabei ;

Nagy, Tamas ;

Pierce, Michael .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (45) :31534-31549

[14] Serum N-glycan analysis in breast cancer patients - Relation to tumour biology and clinical outcome [J].

Haakensen, Vilde D. ;

Steinfeld, Israel ;

Saldova, Radka ;

Shehni, Akram Asadi ;

Kifer, Ilona ;

Naume, Bjorn ;

Rudd, Pauline M. ;

Borresen-Dale, Anne-Lise ;

Yakhini, Zohar .

MOLECULAR ONCOLOGY, 2016, 10 (01) :59-72

[15] β1,6-Branched oligosaccharides are increased in lymph node metastases and predict poor outcome in breast carcinoma [J].

Handerson, T ;

Camp, R ;

Harigopal, M ;

Rimm, D ;

Pawelek, J .

CLINICAL CANCER RESEARCH, 2005, 11 (08) :2969-2973

[16] Linkage-Specific in Situ Sialic Acid Derivatization for N-Glycan Mass Spectrometry Imaging of Formalin-Fixed Paraffin-Embedded Tissues [J].

Holst, Stephanie ;

Heijs, Bram ;

de Haan, Noortje ;

van Zeijl, Rene J. M. ;

Briaire-de Bruijn, Inge H. ;

van Pelt, Gabi W. ;

Mehta, Anand S. ;

Angel, Peggy M. ;

Mesker, Wilma E. ;

Tollenaar, Rob A. ;

Drake, Richard R. ;

Bovee, Judith V. M. G. ;

McDonnell, Liam A. ;

Wuhrer, Manfred .

ANALYTICAL CHEMISTRY, 2016, 88 (11) :5904-5913

[17] N-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression [J].

Holst, Stephanie ;

Deuss, Anna J. M. ;

van Pelt, Gabi W. ;

van Vliet, Sandra J. ;

Garcia-Vallejo, Juan J. ;

Koeleman, Carolien A. M. ;

Deelder, Andre M. ;

Mesker, Wilma E. ;

Tollenaar, Rob A. ;

Rombouts, Yoann ;

Wuhrer, Manfred .

MOLECULAR & CELLULAR PROTEOMICS, 2016, 15 (01) :124-140

[18] Glycosylation Characteristics of Colorectal Cancer [J].

Holst, Stephanie ;

Wuhrer, Manfred ;

Rombouts, Yoann .

GLYCOSYLATION AND CANCER, 2015, 126 :203-256

[19] The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial [J].

Huijbers, A. ;

Tollenaar, R. A. E. M. ;

v Pelt, G. W. ;

Zeestraten, E. C. M. ;

Dutton, S. ;

McConkey, C. C. ;

Domingo, E. ;

Smit, V. T. H. B. M. ;

Midgley, R. ;

Warren, B. F. ;

Johnstone, E. C. ;

Kerr, D. J. ;

Mesker, W. E. .

ANNALS OF ONCOLOGY, 2013, 24 (01) :179-185

[20] Stromal contribution to the colorectal cancer transcriptome [J].

Isella, Claudio ;

Terrasi, Andrea ;

Bellomo, Sara Erika ;

Petti, Consalvo ;

Galatola, Giovanni ;

Muratore, Andrea ;

Mellano, Alfredo ;

Senetta, Rebecca ;

Cassenti, Adele ;

Sonetto, Cristina ;

Inghirami, Giorgio ;

Trusolino, Livio ;

Fekete, Zsolt ;

De Ridder, Mark ;

Cassoni, Paola ;

Storme, Guy ;

Bertotti, Andrea ;

Medico, Enzo .

NATURE GENETICS, 2015, 47 (04) :312-U49

← 1 2 3 4 5 6 →