The protective study about alleviation of simvastatin on the damages of PEG-BNs in mice

被引:7
作者
An, Wenzhen [1 ]
Han, Biao [2 ]
Li, Kang [1 ]
Akhtar, Shahnaz [1 ]
Zhang, Ying [1 ]
Zhang, Xuan [1 ]
Sha, Xueli [1 ]
Gao, Lan [1 ]
机构
[1] Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Gansu, Peoples R China
[2] Lanzhou Univ, Hosp 1, Thorac Surg, Lanzhou 730000, Gansu, Peoples R China
基金
中国国家自然科学基金;
关键词
PEG-BNs; Damages; Simvastatin; Anti-inflammatory; Mice; BORON-NITRIDE NANOTUBES; WALLED CARBON NANOTUBES; STATIN THERAPY; LUNG-CANCER; GRAPHENE; RISK; NANOPARTICLES; BIODISTRIBUTION;
D O I
10.1016/j.etap.2017.04.021
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Boron nitride nanoparticles have been proved to cause various toxicities, damages or inflammations after entering into in viva in previous reports. However, up to now, there are rare investigations about the alleviation of damages caused by nanoparticles in vivo through natural small molecule drugs. Therefore, in this work, PEG-BNs with high solubility was successfully synthesized, and then their biodistribution in mice were studied using radiolabeling technique. And the heart, lung, liver, spleen, kidney tissues and blood samples were done for histology and biochemical analysis. The results showed that PEG-BNs were mainly distributed in lung, liver, kidney and spleen with an obviouse decreasing distribution as the experimental time was increasing. Besides, significantly serum biochemical and tissue pathological changes induced by PEG-BNs were confirmed. Moreover, after simvastatin (SST) exposure to the PEG-BNs model mice, the damages and biochemical indexes were recovered significantly as compared to the single exposure group mice in serum, which indicates a good treatment effect on the toxicity of PEG-BNs in vivo in mice. This study provides some basic data and useful information for the treatment of damages caused by the nanoparticles in mice in the future.
引用
收藏
页码:64 / 73
页数:10
相关论文
共 42 条
[1]   Impact of Rosuvastatin on Contrast-Induced Acute Kidney Injury in Patients at High Risk for Nephropathy Undergoing Elective Angiography [J].
Abaci, Okay ;
Ozkan, Aley Arat ;
Kocas, Cuneyt ;
Cetinkal, Gokhan ;
Karaca, Osman Sukru ;
Baydar, Onur ;
Kaya, Aysem ;
Gurmen, Tevfik .
AMERICAN JOURNAL OF CARDIOLOGY, 2015, 115 (07) :867-871
[2]  
Abdelhalim MAK, 2011, LIPIDS HLTH DIS, V10, P1, DOI DOI 10.1186/1476-511X-10-1
[3]  
[Anonymous], SURF COAT TECHNOL
[4]  
[Anonymous], J SURG CLIN RES
[5]   How do physicochemical properties influence the toxicity of silver nanoparticles on freshwater decomposers of plant litter in streams? [J].
Batista, Daniela ;
Pascoal, Claudia ;
Cassio, Fernanda .
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2017, 140 :148-155
[6]  
Cheungpasitporn W., 2015, REN FAIL, V37, P1
[7]  
Chhowalla M, 2013, NAT CHEM, V5, P263, DOI [10.1038/nchem.1589, 10.1038/NCHEM.1589]
[8]  
Ciofani G, 2014, NANOMEDICINE-UK, V9, P773, DOI [10.2217/nnm.14.25, 10.2217/NNM.14.25]
[9]   Assessing cytotoxicity of boron nitride nanotubes: Interference with the MTT assay [J].
Ciofani, Gianni ;
Danti, Serena ;
D'Alessandro, Delfo ;
Moscato, Stefania ;
Menciassi, Arianna .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 394 (02) :405-411
[10]   Boron nitride nanotube-functionalised myoblast/microfibre constructs: a nanotech-assisted tissue-engineered platform for muscle stimulation [J].
Danti, Serena ;
Ciofani, Gianni ;
Pertici, Gianni ;
Moscato, Stefania ;
D'Alessandro, Delfo ;
Ciabatti, Elena ;
Chiellini, Federica ;
D'Acunto, Mario ;
Mattoli, Virgilio ;
Berrettini, Stefano .
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2015, 9 (07) :847-851