Thermally Activated Transport of Physiologically Active Compounds

被引：1
|
作者：
Valuev, L. I. [1 ]
Valuev, I. L. [1 ]
Plate, N. A. [1 ]
机构：
[1] Russian Acad Sci, Inst Topol & Dynam Syst, Moscow 119991, Russia
来源：
POLYMER SCIENCE SERIES A | 2009年 / 51卷 / 11-12期
基金：
俄罗斯基础研究基金会;
关键词：
CRITICAL SOLUTION TEMPERATURE; POLYMERS;
D O I：
10.1134/S0965545X09110042
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
This survey concerns the potential inherent in the conformational transition of macromolecules that occurs at an LSCT for the targeted transport of physiologically active compounds linked to these macromolecules. Methods for controlling the LSCT of the polymeric carrier are discussed, and relationships between the biological activity of the compounds being transported and their structure and the structure of the polymeric carrier are examined. Approaches ensuring conservation of biological activity via the repeated transition through LCST and providing removal of all components of the system from a living organism are considered. DOI: 10.1134/S0965545X09110042
引用
收藏
页码：1204 / 1209
页数：6
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