Potential Biological Roles of Exosomal Long Non-Coding RNAs in Gastrointestinal Cancer

被引：4

作者：

Kang, Fanhua ^{[1
]}

Jiang, Feng ^{[2
]}

Ouyang, Lingzi ^{[1
]}

Wu, Shangjun ^{[1
]}

Fu, Chencheng ^{[1
]}

Liu, Ying ^{[1
]}

Li, Zhilan ^{[1
]}

Tian, Yu ^{[2
]}

Cao, Xiaolan ^{[2
]}

Wang, Xiaoping ^{[2
]}

He, Qingchun ^{[3
,4
,5
]}

机构：

[1] Xiangya Changde Hosp, Dept Pathol, Changde, Peoples R China

[2] Xizang Minzu Univ, Dept Med, Xianyang, Peoples R China

[3] Cent South Univ, Xiangya Hosp, Dept Emergency, Changsha, Peoples R China

[4] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China

[5] Xiangya Changde Hosp, Dept Emergency, Changde, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2022年 / 10卷

关键词：

gastrointestinal cancer; exosome; lncRNAs; pathogenesis; treatment; COLORECTAL-CANCER; GASTRIC-CANCER; DIAGNOSTIC BIOMARKER; MEDIATED TRANSFER; COLON-CANCER; CELLS; CHEMORESISTANCE; FIBROBLASTS;

D O I：

10.3389/fcell.2022.886191

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Exosomes, a type of extracellular vesicles (EVs), are secreted by almost all cells and contain many cellular constituents, such as nucleic acids, lipids, and metabolites. In addition, they play a crucial role in intercellular communication and have been proved to be involved in the development and treatment of gastrointestinal cancer. It has been confirmed that long non-coding RNAs (lncRNAs) exert a range of biological functions, such as cell metastasis, tumorigenesis, and therapeutic responses. This review mainly focused on the emerging roles and underlying molecular mechanisms of exosome-derived lncRNAs in gastrointestinal cancer in recent years. The biological roles of exosomal lncRNAs in the pathogenesis and therapeutic responses of gastrointestinal cancers were also investigated.

引用

页数：8

共 71 条

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