Intraoperative Radiation Therapy for Breast Cancer

被引：1

作者：

Valente, Stephanie A. ^{[1
]}

Shah, Chirag ^{[2
]}

机构：

[1] Cleveland Clin, Div Breast Surg, Dept Gen Surg, 9500 Euclid Ave,A80, Cleveland, OH 44195 USA

[2] Cleveland Clin, Taussig Canc Inst, Dept Radiat Oncol, Cleveland, OH 44106 USA

来源：

CURRENT BREAST CANCER REPORTS | 2021年 / 13卷 / 03期

关键词：

Breast cancer; Radiation; Intraoperative radiation therapy; IORT; Partial breast radiation; TARGIT-A; ELIOT; 20-YEAR FOLLOW-UP; TARGIT-A TRIAL; CONSERVING SURGERY; RANDOMIZED TRIAL; X-RAYS; RADIOTHERAPY; IRRADIATION; PHASE-3; BRACHYTHERAPY; LUMPECTOMY;

D O I：

10.1007/s12609-021-00411-5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose of Review Adjuvant radiation represents a standard approach following breast conserving surgery. While traditionally delivered as whole breast irradiation (WBI), an alternative has emerged with the development of partial breast irradiation techniques. One such technique is intraoperative radiation therapy (IORT). The purpose of this review is to discuss the studies evaluating IORT as well as evaluating current guidelines and future directions. Recent Findings Review of two randomized trials (TARGIT-A and ELIOT) demonstrates that breast cancer patients treated with IORT had a higher risk of local recurrence (LR). However, patients with low-risk features and IORT performed at the time of surgery had similar rates of LR at 5 years, with longer follow-up needed. IORT as a boost is promising, and studies are ongoing. Further studies are needed to validate the role of IORT and which patients are appropriate for IORT, and longer follow-up is needed.

引用

页码：157 / 163

页数：7

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