Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis

被引：170

作者：

Li, Wei ^{[1
,2
]}

Xie, Li ^{[1
]}

Chen, Zheng ^{[1
]}

Zhu, Yi ^{[1
]}

Sun, Yujie ^{[2
,3
]}

Miao, Yi ^{[1
,3
]}

Xu, Zekuan ^{[1
,3
]}

Han, Xiao ^{[2
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Gen Surg, Nanjing, Peoples R China

[2] Nanjing Med Univ, Key Lab Human Funct Genom Jiangsu Prov, Nanjing, Peoples R China

[3] Nanjing Med Univ, Ctr Canc, Nanjing, Peoples R China

来源：

CANCER SCIENCE | 2010年 / 101卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ANAPHASE-PROMOTING COMPLEX; TRAIL-INDUCED APOPTOSIS; PROTEIN PHOSPHATASE 2A; FLOW-CYTOMETRY; EXPRESSION; PATHWAYS; LINES; NORCANTHARIDIN; SENSITIVITY; MECHANISMS;

D O I：

10.1111/j.1349-7006.2010.01523.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

(Cancer Sci 2010; 101: 1226-1233).

引用

页码：1226 / 1233

页数：8

共 47 条

[21] Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation [J].

Kyriakis, JM ;

Avruch, J .

PHYSIOLOGICAL REVIEWS, 2001, 81 (02) :807-869

[22] Pancreatic cancer [J].

Li, DH ;

Xie, KP ;

Wolff, R ;

Abbruzzese, JL .

LANCET, 2004, 363 (9414) :1049-1057

[23] Islet neogenesis-associated protein-related pentadecapeptide enhances the differentiation of islet-like clusters from human pancreatic duct cells [J].

Li, Juan ;

Wang, Yun ;

Yu, Xiaozhu ;

Chen, Haiyan ;

Wu, Ying ;

Han, Xiao ;

Guo, Xirong ;

Zhang, Chenyu ;

Chen, Qi ;

Chen, Jiawei ;

Yang, Tao .

PEPTIDES, 2009, 30 (12) :2242-2249

[24] Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation [J].

Lin, Kuei-Li ;

Su, Jung-Chen ;

Chien, Ching-Ming ;

Tseng, Chih-Hua ;

Chen, Yeh-Long ;

Chang, Long-Sen ;

Lin, Shinne-Ren .

TOXICOLOGY IN VITRO, 2010, 24 (01) :61-70

[25] Correlation of thymidylate synthase, thymidine phosphorylase and dihydropyrimidine dehydrogenase with sensitivity of gastrointestinal cancer cells to 5-fluorouracil and 5-fluoro-2′-deoxyuridine [J].

Ma, T ;

Zhu, ZG ;

Ji, YB ;

Zhang, Y ;

Yu, YY ;

Liu, BY ;

Yin, HR ;

Lin, YZ .

WORLD JOURNAL OF GASTROENTEROLOGY, 2004, 10 (02) :172-176

[26] Regulation of protein kinase cascades by protein phosphatase 2A [J].

Millward, TA ;

Zolnierowicz, S ;

Hemmings, BA .

TRENDS IN BIOCHEMICAL SCIENCES, 1999, 24 (05) :186-191

[27] Genetic profile of 22 pancreatic carcinoma cell lines -: Analysis of K-ras, p53, p16 and DPC4/Smad4 [J].

Moore, PS ;

Sipos, B ;

Orlandini, S ;

Sorio, C ;

Real, FX ;

Lemoine, NR ;

Gress, T ;

Bassi, C ;

Klöppel, G ;

Kalthoff, H ;

Ungefroren, H ;

Löhr, M ;

Scarpa, A .

VIRCHOWS ARCHIV, 2001, 439 (06) :798-802

[28] Regulation of the resistance to TRAIL-induced apoptosis as a new strategy for pancreatic cancer [J].

Mori, T ;

Doi, R ;

Toyoda, E ;

Koizumi, M ;

Ito, D ;

Kami, K ;

Kida, A ;

Masui, T ;

Kawaguchi, Y ;

Fujimoto, K .

SURGERY, 2005, 138 (01) :71-77

[29] A RAPID AND SIMPLE METHOD FOR MEASURING THYMOCYTE APOPTOSIS BY PROPIDIUM IODIDE STAINING AND FLOW-CYTOMETRY [J].

NICOLETTI, I ;

MIGLIORATI, G ;

PAGLIACCI, MC ;

GRIGNANI, F ;

RICCARDI, C .

JOURNAL OF IMMUNOLOGICAL METHODS, 1991, 139 (02) :271-279

[30] Oxidative stress and apoptosis: impact on cancer therapy [J].

Ozben, Tomris .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2007, 96 (09) :2181-2196

← 1 2 3 4 5 →