Cantharidin, a potent and selective PP2A inhibitor, induces an oxidative stress-independent growth inhibition of pancreatic cancer cells through G2/M cell-cycle arrest and apoptosis

被引:170
作者
Li, Wei [1 ,2 ]
Xie, Li [1 ]
Chen, Zheng [1 ]
Zhu, Yi [1 ]
Sun, Yujie [2 ,3 ]
Miao, Yi [1 ,3 ]
Xu, Zekuan [1 ,3 ]
Han, Xiao [2 ]
机构
[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Gen Surg, Nanjing, Peoples R China
[2] Nanjing Med Univ, Key Lab Human Funct Genom Jiangsu Prov, Nanjing, Peoples R China
[3] Nanjing Med Univ, Ctr Canc, Nanjing, Peoples R China
基金
中国国家自然科学基金;
关键词
ANAPHASE-PROMOTING COMPLEX; TRAIL-INDUCED APOPTOSIS; PROTEIN PHOSPHATASE 2A; FLOW-CYTOMETRY; EXPRESSION; PATHWAYS; LINES; NORCANTHARIDIN; SENSITIVITY; MECHANISMS;
D O I
10.1111/j.1349-7006.2010.01523.x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
(Cancer Sci 2010; 101: 1226-1233).
引用
收藏
页码:1226 / 1233
页数:8
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