Integration of Systemic and Liver-Directed Therapies for Locally Advanced Hepatocellular Cancer: Harnessing Potential Synergy for New Therapeutic Horizons

被引：6
作者：
Bent, Eric H. [1 ]
Wehrenberg-Klee, Eric [2 ]
Koay, Eugene J. [3 ]
Goyal, Lipika [4 ]
Wo, Jennifer Y. [1 ]
机构：
[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiat Oncol, Boston, MA 02115 USA
[2] Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Div Intervent Radiol, Boston, MA 02115 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Radiat Oncol, Houston, TX 77030 USA
[4] Harvard Med Sch, Massachusetts Gen Hosp, Dept Med, Div Hematol & Oncol, Boston, MA 02115 USA
来源：
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK | 2021年 / 19卷 / 05期
关键词：
STEREOTACTIC BODY RADIOTHERAPY; IMMUNOGENIC CELL-DEATH; TRANSARTERIAL CHEMOEMBOLIZATION; RADIOFREQUENCY ABLATION; CHECKPOINT BLOCKADE; RADIATION-THERAPY; DOUBLE-BLIND; PHASE-I; CARCINOMA; SORAFENIB;
D O I：
10.6004/jnccn.2021.7037
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Treatment options in locally advanced hepatocellular carcinoma (HCC) have evolved considerably over the past few years with the recent approval of multiple systemic therapies and significant advances in locoregional therapy. Given the poor prognosis for patients with unresectable HCC, there is significant interest in rationally designed combination therapies. This article reviews the treatment options available to patients with locally advanced HCC and discusses the rationale, ongoing trials, and future prospects for combining locoregional and systemic therapy in both the definitive and neoadjuvant settings. J Natl Compr Canc Netw 2021;19(5):567-576 doi: 10.6004/jnccn.2021.7037
引用
收藏
页码：567 / +
页数：12
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