Brain endothelial LRP1 maintains blood-brain barrier integrity

被引：22
作者：
Storck, Steffen E. [1 ]
Kurtyka, Magdalena [1 ]
Pietrzik, Claus U. [1 ]
机构：
[1] Johannes Gutenberg Univ Mainz, Inst Pathobiochem, Mol Neurodegenerat, Univ Med Ctr, Duesbergweg 6, D-55099 Mainz, Germany
来源：
FLUIDS AND BARRIERS OF THE CNS | 2021年 / 18卷 / 01期
关键词：
Blood-brain barrier integrity; Low-density lipoprotein receptor-related protein 1 (LRP1); P-glycoprotein; Abcb1 (P-gp); Tight junctions; Matrix metalloproteinases (MMPs); Cyclophillin A; ABC TRANSPORTERS; TARGETS; MODEL; CNS;
D O I：
10.1186/s12987-021-00260-5
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The entry of blood-borne molecules into the brain is restricted by the blood-brain barrier (BBB). Various physical, transport and immune properties tightly regulate molecule movement between the blood and the brain to maintain brain homeostasis. A recent study utilizing a pan-endothelial, constitutive Tie2-Cre showed that paracellular passage of blood proteins into the brain is governed by endocytic and cell signaling protein low-density lipoprotein receptor-related protein 1 (LRP1). Taking advantage of conditional Slco1c1-CreER(T2) specific to CNS endothelial cells and choroid plexus epithelial cells we now supplement previous results and show that brain endothelial Lrp1 ablation results in protease-mediated tight junction degradation, P-glycoprotein (P-gp) reduction and a loss of BBB integrity.
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页数：7
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