Micro- and nano-patterned conductive graphene-PEG hybrid scaffolds for cardiac tissue engineering

被引：94

作者：

Smith, Alec S. T. ^{[1
,6
,7
]}

Yoo, Hyok ^{[1
]}

Yi, Hyunjung ^{[2
]}

Ahn, Eun Hyun ^{[3
,7
]}

Lee, Justin H. ^{[1
]}

Shao, Guozheng ^{[4
]}

Nagornyak, Ekaterina ^{[1
,5
]}

Laflamme, Michael A. ^{[6
]}

Murry, Charles E. ^{[1
,3
,5
,6
,7
]}

Kim, Deok-Ho ^{[1
,6
,7
]}

机构：

[1] Univ Washington, Dept Bioengn, Seattle, WA 98195 USA

[2] Korea Inst Sci & Technol, Postsilicon Semicond Inst, Seoul 02792, South Korea

[3] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[4] Univ Washington, Dept Chem, Seattle, WA 98195 USA

[5] Univ Washington, Dept Med Cardiol, Seattle, WA 98195 USA

[6] Univ Washington, Ctr Cardiovasc Biol, Seattle, WA 98195 USA

[7] Univ Washington, Inst Stem Cell & Regenerat Med, Seattle, WA 98195 USA

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 53期

关键词：

CARDIOMYOCYTES; CONSTRUCTS; MUSCLE;

D O I：

10.1039/c7cc01988b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A lack of electrical conductivity and structural organization in currently available biomaterial scaffolds limits their utility for generating physiologically representative models of functional cardiac tissue. Here we report on the development of scalable, graphene-functionalized topographies with anisotropic electrical conductivity for engineering the structural and functional phenotypes of macroscopic cardiac tissue constructs. Guided by anisotropic electroconductive and topographic cues, the tissue constructs displayed structural property enhancement in myofibrils and sarcomeres, and exhibited significant increases in the expression of cell-cell coupling and calcium handling proteins, as well as in action potential duration and peak calcium release.

引用

页码：7412 / 7415

页数：4

共 20 条

[1]

Banhart F, 2011, ACS NANO, V5, P26, DOI [10.1021/nn102598m, 10.1016/B978-0-08-102053-1.00005-3]

[2] Nanotopography-Induced Structural Anisotropy and Sarcomere Development in Human Cardiomyocytes Derived from Induced Pluripotent Stem Cells [J].