Palladium catalysed coupling of iodoquinolines and acetylenes - A novel entry to the pyrrolo[3,2,1-ij]-quinoline nucleus

被引：0

作者：

Blurton, P ^{[1
]}

Brickwood, A ^{[1
]}

Dhanak, D ^{[1
]}

机构：

[1] SmithKline Beecham Pharmaceut, Collegeville, PA 19426 USA

来源：

HETEROCYCLES | 1997年 / 45卷 / 12期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 4-arylamino-8-iodoquinoline derivatives with propargyl alcohol and triethylamine in the presence of iodo(phenyl)bis(triphenylphosphine) palladium and copper(I)iodide gives 6-imino-substituted pyrrolo[3,2,-ij]quinolines under mild conditions and in moderate yields. Catalytic hydrogenation over Lindlar's catalyst affords functionalised 4H-pyrrolo[3,2,1-ij]quinolines in good yield.

引用

页码：2395 / 2403

页数：9

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