Palladium catalysed coupling of iodoquinolines and acetylenes - A novel entry to the pyrrolo[3,2,1-ij]-quinoline nucleus

被引：0
作者：
Blurton, P [1 ]
Brickwood, A [1 ]
Dhanak, D [1 ]
机构：
[1] SmithKline Beecham Pharmaceut, Collegeville, PA 19426 USA
来源：
HETEROCYCLES | 1997年 / 45卷 / 12期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of 4-arylamino-8-iodoquinoline derivatives with propargyl alcohol and triethylamine in the presence of iodo(phenyl)bis(triphenylphosphine) palladium and copper(I)iodide gives 6-imino-substituted pyrrolo[3,2,-ij]quinolines under mild conditions and in moderate yields. Catalytic hydrogenation over Lindlar's catalyst affords functionalised 4H-pyrrolo[3,2,1-ij]quinolines in good yield.
引用
收藏
页码：2395 / 2403
页数：9
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