Breast cancer metastasis suppressor 1: Update

被引：48
|
作者：
Meehan, WJ
Welch, DR
机构：
[1] Univ Alabama, Natl Fdn Canc Res Ctr Metastasis Res, Birmingham, AL 35294 USA
[2] Penn State Univ, Coll Med, Jake Gittlen Canc Res Inst, Hershey, PA USA
来源：
CLINICAL & EXPERIMENTAL METASTASIS | 2003年 / 20卷 / 01期
关键词：
breast cancer; BRMS1; melanoma; metastasis suppressor gene; gap junctional intercellular communication;
D O I：
10.1023/A:1022542519586
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
This article reviews information related to the BRMS1 (BReast Metastasis Suppressor 1) metastasis suppressor gene. BRMS1 was identified by differential display comparing metastasis-suppressed chromosome 11 hybrids with metastatic, parental MDA-MB-435 human breast carcinoma cells. BRMS1 has subsequently been shown to suppress metastasis, but not tumorigenicity of human melanoma cells. The murine version, Brms1, also suppresses metastasis and exhibits a high level of homology to the human gene at the structure, nucleotide and amino acid levels. The mechanisms of action remain to be determined; however, BRMS1 transfectant cells have restored gap junctional intercellular communication. Recent data suggest that BRMS1 is part of the mSin3A histone deacetylase complex.
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收藏
页码：45 / 50
页数：6
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