Photodynamic therapy for treatment of infected burns

被引：9

作者：

da Fonseca, Adenilson de Souza ^{[1
,2
,3
]}

de Paoli, Flavia ^{[4
]}

Mencalha, Andre Luiz ^{[1
]}

机构：

[1] Univ Estado Rio De Janeiro, Dept Biofis & Biometria, Inst Biol Roberto Alcantara Gomes, Blvd Vinte & Oito Setembro, 87, BR-20551030 Rio De Janeiro, Brazil

[2] Univ Fed Estado Rio Janeiro, Dept Ciencias Fisiol, Inst Biomed, Rua Frei Caneca, 94, BR-20211040 Rio De Janeiro, Brazil

[3] Ctr Univ Serra Orgaos, Ctr Ciencias Saude, Ave Alberto Torres, 111, BR-25964004 Teresopolis, RJ, Brazil

[4] Univ Fed Juiz Fora, Inst Ciencias Biol, Dept Morfol, Rua Jose Lourenco Khelmer-s-n,Campus Univ, BR-36036900 Juiz De Fora, MG, Brazil

来源：

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2022年 / 38卷

关键词：

Bacteria; Burn; Fungi; Photodynamic therapy; Virus; injury; TOLUIDINE BLUE O; IN-VITRO; STAPHYLOCOCCUS-AUREUS; PHOTOSENSITIZERS; NANOPARTICLES; EPIDEMIOLOGY; INACTIVATION; MANAGEMENT; RESISTANCE; STRAINS;

D O I：

10.1016/j.pdpdt.2022.102831

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Burns are among the most debilitating and devastating forms of trauma. Such injuries are influenced by in-fections, causing increased morbidity, mortality, and healthcare costs. Due to the emergence of multidrug-resistant infectious agents, efficient treatment of infections in burns is a challenging issue. Antimicrobial photodynamic therapy (aPDT) is a promising approach to inactivate infectious agents, including multidrug-resistant. In this review, studies on PubMed were gathered, aiming to summarize the achievements regarding the applications of antimicrobial photodynamic therapy for the treatment of infected burns. A literature search was carried out for aPDT published reports assessment on bacterial, fungal, and viral infections in burns. The collected data suggest that aPDT could be a promising new approach against multidrug-resistant infectious agents. However, despite important results being obtained against bacteria, experimental and clinical studies are necessary yet on the effectiveness of aPDT against fungal and viral infections in burns, which could reduce morbidity and mortality of burned patients, mainly those infected by multidrug-resistant strains.

引用

页数：7