New Insights into the Copper-Catalyzed Alkylation of Grignard and Organolithium Reagents

被引：23

作者：

Cahiez, Gerard ^{[1
]}

Gager, Olivier ^{[1
]}

Buendia, Julien ^{[1
]}

机构：

[1] Univ Paris 13, CNRS, Dept Chem, F-93017 Bobigny, France

来源：

SYNLETT | 2010年 / 02期

关键词：

alkylations; copper; cross-coupling; Grignard reactions; organometallic reagents; VINYL ORGANOCOPPER COMPOUNDS; STEREOSPECIFIC SYNTHESIS; ORGANOMETALLIC COMPOUNDS; PHENYLLITHIUM; DERIVATIVES; CARBONATION; CHEMISTRY; ACIDS;

D O I：

10.1055/s-0029-1219222

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Until now, it was considered that the copper-catalyzed alkylation of Grignard reagents gave good yields only in the presence of ligands, such as NMP or 1-phenylpropyne. We show herein that a slow and regular addition of the Grignard reagent provides similar results. With secondary and tertiary alkyl Grignard reagents, we disclosed that the presence of benzonitrile (10 mol%), a very simple ligand, is very efficient. The copper-catalyzed alkylation of organolithium compounds was also studied.

引用

页码：299 / 303

页数：5

共 32 条

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