Human dental pulp stem cells and hormesis

被引：14

作者：

Calabrese, Edward J. ^{[1
]}

Agathokleous, Evgenios ^{[2
]}

Dhawan, Gaurav ^{[3
]}

Kapoor, Rachna ^{[4
]}

Calabrese, Vittorio ^{[5
]}

机构：

[1] Univ Massachusetts, Dept Environm Hlth Sci, Morrill 1,N344, Amherst, MA 01003 USA

[2] Nanjing Univ Informat Sci & Technol, Sch Appl Meteorol, Nanjing 210044, Peoples R China

[3] Univ Hlth Sci, Sri Guru Ram SGRD, Amritsar, Punjab, India

[4] St Francis Hosp & Med Ctr, Hartford, CT USA

[5] Univ Catania, Sch Med, Dept Biomed & Biotechnol Sci, Via Santa Sofia 97, I-95125 Catania, Italy

来源：

AGEING RESEARCH REVIEWS | 2022年 / 73卷

关键词：

Hormesis; Biphasic dose response; Stem cell; Dental pulp stem cells; Cell differentiation; Cell proliferation; ACTIVATED PROTEIN-KINASE; HORMETIC DOSE RESPONSES; NECROSIS-FACTOR-ALPHA; OSTEOGENIC DIFFERENTIATION; ATP RELEASE; ODONTOBLASTIC DIFFERENTIATION; OSTEOBLASTIC DIFFERENTIATION; ADENOSINE-TRIPHOSPHATE; HISTORICAL FOUNDATIONS; RADIATION HORMESIS;

D O I：

10.1016/j.arr.2021.101540

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This paper represents the first assessment of hormetic dose responses by human dental pulp stem cells (hDPSCs) with particular emphasis on cell renewal (proliferation) and differentiation. Hormetic dose responses were commonly reported in this model, encompassing a broad range of chemicals, including principally pharmaceuticals (e.g., metformin and artemisinin), dietary supplements/extracts from medicinal plants (e.g., berberine, N-acetyl-L-cysteine, and ginsenoside Rg1) and endogenous agents (e.g., ATP, TNF-alpha). The paper assesses mechanistic foundations of the hDPSCs hormetic dose responses for both cell proliferation and cell differentiation, study design considerations, and therapeutic implications.

引用

页数：11

共 86 条

[1] Systemic Herbicide 2,4-Dichlorophenoxyacetic Acid Is Another Hormetin: What Does It Mean for Agriculture and the Environment? [J].

Agathokleous, Evgenios ;

Feng, Zhaozhong ;

Calabrese, Edward J. .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 67 (35) :9695-9696

[2]

Aguilar J.V., 2021, J ENV SCI HLTH B, V18, P1

[3]

Asl Aminabadi Naser, 2013, J Dent Res Dent Clin Dent Prospects, V7, P8, DOI 10.5681/joddd.2013.002

[4]

Calabrese EJ, 2008, ENVIRON TOXICOL CHEM, V27, P1451, DOI 10.1897/07-541

[5] Human periodontal ligament stem cells and hormesis: Enhancing cell renewal and cell differentiation [J].

Calabrese, Edward J. .

PHARMACOLOGICAL RESEARCH, 2021, 173

[6] The hormetic dose-response mechanism: Nrf2 activation [J].

Calabrese, Edward J. ;

Kozumbo, Walter J. .

PHARMACOLOGICAL RESEARCH, 2021, 167

[7] Hormesis and Ginseng: Ginseng Mixtures and Individual Constituents Commonly Display Hormesis Dose Responses, Especially for Neuroprotective Effects [J].

Calabrese, Edward J. .

MOLECULES, 2020, 25 (11)

[8] How does hormesis impact biology, toxicology, and medicine? [J].

Calabrese E.J. ;

Mattson M.P. .

npj Aging and Mechanisms of Disease, 3 (1)

[9] HORMESIS: A Fundamental Concept with Widespread Biological and Biomedical Applications [J].

Calabrese, Edward J. ;

Dhawan, Gaurav ;

Kapoor, Rachna ;

Iavicoli, Ivo ;

Calabrese, Vittorio .

GERONTOLOGY, 2016, 62 (05) :530-535

[10] Preconditioning is hormesis part II: How the conditioning dose mediates protection: Dose optimization within temporal and mechanistic frameworks [J].

Calabrese, Edward J. .

PHARMACOLOGICAL RESEARCH, 2016, 110 :265-275

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