Neuroprotective delivery platforms as an adjunct to mechanical thrombectomy

被引：21
作者：
Babadjouni, Robin M. [1 ]
Walcott, Brian P. [2 ]
Liu, Qinghai [1 ]
Tenser, Matthew S. [2 ]
Amar, Arun P. [2 ]
Mack, William J. [1 ,2 ]
机构：
[1] Univ Southern Calif, Keck Sch Med, Zilkha Neurogenet Inst, Los Angeles, CA USA
[2] Univ Southern Calif, Keck Sch Med, Dept Neurosurg, Los Angeles, CA USA
来源：
NEUROSURGICAL FOCUS | 2017年 / 42卷 / 04期
基金：
美国国家卫生研究院;
关键词：
acute ischemic stroke; mechanical thrombectomy; neuroprotection; ACUTE ISCHEMIC-STROKE; HEALTH-CARE PROFESSIONALS; CEREBRAL VASOSPASM; RANDOMIZED-TRIALS; EARLY MANAGEMENT; STATIN THERAPY; DOUBLE-BLIND; ENDOVASCULAR THROMBECTOMY; INTRAARTERIAL NIMODIPINE; SUBARACHNOID HEMORRHAGE;
D O I：
10.3171/2017.1.FOCUS16514
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Despite the success of numerous neuroprotective strategies in animal and preclinical stroke models, none have effectively translated to clinical medicine. A multitude of influences are likely responsible. Two such factors are inefficient recanalization strategies for large vessel occlusions and suboptimal delivery methods/platforms for neuroprotective agents. The recent endovascular stroke trials have established a new paradigm for large vessel stroke treatment. The associated advent of advanced mechanical revascularization devices and new stroke technologies help address each of these existing gaps. A strategy combining effective endovascular revascularization with administration of neuroprotective therapies is now practical and could have additive, if not synergistic, effects. This review outlines past and current neuroprotective strategies assessed in acute stroke trials. The discussion focuses on delivery platforms and their potential applicability to endovascular stoke treatment.
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页数：11
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