Oximinotrifluoromethylation of unactivated alkenes under ambient conditions

被引：44

作者：

Wang, Na ^{[1
,2
,3
]}

Wang, Jian ^{[2
,3
]}

Guo, Yu-Long ^{[2
,3
]}

Li, Lei ^{[2
,3
]}

Sun, Yan ^{[2
,3
]}

Li, Zhuang ^{[2
,3
]}

Zhang, Hong-Xia ^{[1
]}

Guo, Zhen ^{[1
]}

Li, Zhong-Liang ^{[4
]}

Liu, Xin-Yuan ^{[2
,3
]}

机构：

[1] Taiyuan Univ Technol, Key Lab Interface Sci & Engn Adv Mat, Minist Educ, Coll Mat Sci & Engn, Taiyuan 030024, Shanxi, Peoples R China

[2] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Peoples R China

[3] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen 518055, Peoples R China

[4] Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518055, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 64期

基金：

中国国家自然科学基金;

关键词：

COPPER-CATALYZED TRIFLUOROMETHYLATION; LIGHT PHOTOREDOX CATALYSIS; MEDIUM-SIZED RINGS; VISIBLE-LIGHT; FLUOROALKYLSULFONYL CHLORIDES; MIGRATION STRATEGY; RADICAL REACTIONS; CYANO MIGRATION; BOND FORMATION; CONSTRUCTION;

D O I：

10.1039/c8cc05186k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient protocol for oximinotrifluoromethylation of unactivated alkenes was developed via trifluoromethyl radical-induced intramolecular remote oximino migration under mild reaction conditions, providing a wide range of -trifluoromethylated oximes. Other fluoroalkyl radicals were also applicable for this transformation. This method provided access to synthetically challenging medium-sized ring scaffolds and the 6,7,5-fused lactam skeleton.

引用

页码：8885 / 8888

页数：4

共 65 条

[1] CYANO OR ACYL GROUP MIGRATION BY CONSECUTIVE HOMOLYTIC ADDITION AND BETA-FISSION [J].