Long non-coding RNA OIP5-AS1 serves as an oncogene in laryngeal squamous cell carcinoma by regulating miR-204-5p/ZEB1 axis

被引：20
作者：
Wang, Hui [1 ]
Qian, Jiantong [2 ]
Xia, Xiaojing [3 ]
Ye, Ben [4 ]
机构：
[1] Heze Mudan Peoples Hosp, Dept Otorhinolaryngol, Heze City 274000, Shandong, Peoples R China
[2] Juxian Tradit Chinese Med Hosp, Dept Otorhinolaryngol, Rizhao City 276500, Shandong, Peoples R China
[3] Peoples Liberat Army 960 Hosp, Disinfect Supply Ctr, Jinan 250000, Shandong, Peoples R China
[4] Shandong Prov Hosp, Dept Otorhinolaryngol, 324 Jingwu Rd, Jinan 250000, Shandong, Peoples R China
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2020年 / 393卷 / 11期
关键词：
Laryngeal squamous cell carcinoma; Long non-coding RNA OIP5-AS1; Epithelial-mesenchymal transition; microRNA-204-5p; EPITHELIAL-MESENCHYMAL TRANSITION; METASTASIS; EXPRESSION; CANCER; PROLIFERATION; INVASION;
D O I：
10.1007/s00210-020-01811-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Laryngeal squamous cell carcinoma (LSCC) is the most common type of laryngeal cancer with poor prognosis. In the present study, we aimed to investigate the biological role of long non-coding RNA OIP5-AS1 in LSCC. The results demonstrated that the expression levels of OIP5-AS1 were significantly increased in LSCC tissues and cell lines. High expression of OIP5-AS1 was closely correlated with lymph node metastasis and advanced clinical stage of LSCC patients. Moreover, in vitro assays showed that OIP5-AS1 overexpression promoted the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of LSCC cells, whereas OIP5-AS1 knockdown exerted suppressive effects on LSCC cells. Furthermore, OIP5-AS1 was confirmed to serve as a competing endogenous RNA of miR-204-5p in LSCC cells, and restoration of miR-204-5p counteracted the OIP5-AS1-mediated oncogenic effects. In conclusion, our study provides promising evidence that lncRNA OIP5-AS1 functions as a tumor promoter in LSCC and may be used as a potential target for LSCC therapy.
引用
收藏
页码：2177 / 2184
页数：8
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