Pathogenesis of non-alcoholic fatty liver disease

被引：16

作者：

Anty, Rodolphe ^{[1
]}

Gual, Philippe ^{[2
]}

机构：

[1] Univ Cote Azur, CHU Nice, INSERM, C3M,U1065, F-06000 Nice, France

[2] Univ Cote Azur, INSERM, C3M, U1065, F-06000 Nice, France

来源：

PRESSE MEDICALE | 2019年 / 48卷 / 12期

关键词：

ADIPOSE-TISSUE; GUT MICROBIOME; OBESE-PATIENTS; PROGRESSION; NASH; STEATOHEPATITIS; STEATOSIS; FIBROSIS; PROTEIN; CELLS;

D O I：

10.1016/j.lpm.2019.09.051

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Non-Alcoholic Fatty Liver Disease (NAFLD) is a complex chronic disease resulting from an interaction between genetic and environmental factors. The phenotype and pathophysiology of NAFLD is heterogeneous. NAFLD is a continuum of histological lesions of the liver from steatosis, Non-Alcoholic Steato-Hepatitis (NASH), NASH with fibrosis, cirrhosis to hepatocellular carcinoma. The pathophysiology encompasses a dysfunction in fatty tissue (sub-cutaneous and visceral) associated with insulin-resistance and metabolic inflammation. NAFLD is a "multi-systemic'' disease. Reciprocal and aggravating interactions exist between NAFLD, cardiovascular anomalies and diabetes. The understanding of the mechanisms responsible for NAFLD allows the identification of potential novel therapeutic targets.

引用

页码：1468 / 1483

页数：16

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