Hyaluronic acid-based supramolecular medicine with polyamines sequestration capability for cooperative anti-psoriasis

被引：13

作者：

Ding, Yuan-Fu ^{[1
,2
]}

Wei, Jianwen ^{[1
]}

Quan, Xingping ^{[1
]}

Gu, Wenting ^{[1
]}

Xi, Long ^{[1
]}

Zheng, Ying ^{[1
,3
]}

Zhao, Yonghua ^{[1
,3
]}

Luo, Jingwei ^{[4
]}

Li, Shengke ^{[1
]}

Mok, Greta S. P. ^{[2
]}

Wang, Ruibing ^{[1
,3
]}

机构：

[1] Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China

[2] Univ Macau, Dept Elect & Comp Engn, Biomed Imaging Lab BIG, Taipa, Macao, Peoples R China

[3] Univ Macau, Fac Hlth Sci, Dept Pharmaceut Sci, Taipa, Macao, Peoples R China

[4] UltraSpec Lab, Victoria, BC V8P 2N1, Canada

来源：

CARBOHYDRATE POLYMERS | 2022年 / 296卷

基金：

中国国家自然科学基金;

关键词：

CD-44; targeting; Host-guest interactions; Controlled release; Polyamine sequestration; Cooperative anti-psoriasis; CURCUMIN; CELLS; DRUG; OXALIPLATIN; MECHANISMS; RELEASE;

D O I：

10.1016/j.carbpol.2022.119968

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Psoriasis seriously harms physical and mental health of patients. Hyaluronic acid (HA)-based topical formulation can increase drug concentration in psoriatic skin via CD44-assisted targeting. Herein, we developed a supra -molecular medicine composed of curcumin-loaded HA-cucurbit[7]uril (HA-CB[7]@Cur), which could efficiently sequester polyamines (PAs) via host-guest interactions of CB[7] and PAs to suppress RNA-PAs immunocomplex formation. Meanwhile, anti-psoriasis drug Cur could be released from HA-CB[7]@Cur by PAs. With phenotypical disease evaluation, psoriasis area measurements and severity index scoring, and histological characterizations, we demonstrate topical administration of Carbopol gel formulation of HA-CB[7]@Cur on psoriasis-like skin in mice exhibited an enhanced anti-psoriasis activity, in comparison with gel of free Cur or HA-CB[7]. Cytokine expression analysis in psoriatic skin also supported the observed therapeutic outcomes. We provide a novel and effective supramolecular strategy to realize cooperative anti-psoriasis via controlled release of curcumin and PAs sequestration, which can be potentially expanded to treat other PA-involved skin inflammatory diseases.

引用

页数：9

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