Genetic Epidemiology of Attention Deficit Hyperactivity Disorder (ADHD Index) in Adults

被引：101

作者：

Boomsma, Dorret I. ^{[1
]}

Saviouk, Viatcheslav ^{[1
]}

Hottenga, Jouke-Jan ^{[1
]}

Distel, Marijn A. ^{[1
]}

de Moor, Marleen H. M. ^{[1
]}

Vink, Jacqueline M. ^{[1
]}

Geels, Lot M. ^{[1
]}

van Beek, Jenny H. D. A. ^{[1
]}

Bartels, Meike ^{[1
]}

de Geus, Eco J. C. ^{[1
]}

Willemsen, Gonneke ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Dept Biol Psychol, Amsterdam, Netherlands

来源：

PLOS ONE | 2010年 / 5卷 / 05期

关键词：

DEFICIT/HYPERACTIVITY DISORDER; PREVALENCE; HERITABILITY; METAANALYSIS; DEPRESSION; SYMPTOMS; GENOTYPE; HEALTH; FAMILY; TWINS;

D O I：

10.1371/journal.pone.0010621

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Context: In contrast to the large number of studies in children, there is little information on the contribution of genetic factors to Attention Deficit Hyperactivity Disorder (ADHD) in adults. Objective: To estimate the heritability of ADHD in adults as assessed by the ADHD index scored from the CAARS (Conners' Adult ADHD Rating Scales). Design: Phenotype data from over 12,000 adults (twins, siblings and parents) registered with the Netherlands Twin Register were analyzed using genetic structural equation modeling. Main outcome measures: Heritability estimates for ADHD from the twin-family study. Results: Heritability of ADHD in adults is estimated around 30% in men and women. There is some evidence for assortative mating. All familial transmission is explained by genetic inheritance, there is no support for the hypothesis that cultural transmission from parents to offspring is important. Conclusion: Heritability for ADHD features in adults is present, but is substantially lower than it is in children.

引用

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