Glyburide, a NLRP3 Inhibitor, Decreases Inflammatory Response and Is a Candidate to Reduce Pathology in Leishmania braziliensis Infection

被引：39
作者：
Carvalho, Augusto M. [1 ,2 ,3 ]
Novais, Fernanda O. [3 ]
Paixao, Camilla S. [1 ]
de Oliveira, Camila I. [1 ]
Lima Machado, Paulo Roberto [1 ,2 ,4 ]
Carvalho, Lucas P. [1 ,2 ,4 ]
Scott, Phillip [3 ]
Carvalho, Edgar M. [1 ,2 ,4 ]
机构：
[1] Fiocruz MS, Inst Goncalo Moniz, Salvador, BA, Brazil
[2] Univ Fed Bahia, Hosp Univ Prof Edgard Santos, Serv Imunol, Salvador, BA, Brazil
[3] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
[4] INCT DT, Salvador, BA, Brazil
来源：
JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2020年 / 140卷 / 01期
基金：
美国国家卫生研究院;
关键词：
GLIBENCLAMIDE; RESISTANCE; IL-1-BETA;
D O I：
10.1016/j.jid.2019.05.025
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
[No abstract available]
引用
收藏
页码：246 / +
页数：12
相关论文
共 15 条
  • [1] The Role of Nitric Oxide and Reactive Oxygen Species in the Killing of Leishmania braziliensis by Monocytes from Patients with Cutaneous Leishmaniasis
    Carneiro, Pedro Paulo
    Conceicao, Jacilara
    Macedo, Michael
    Magalhaes, Viviane
    Carvalho, Edgar M.
    Bacellar, Olivia
    [J]. PLOS ONE, 2016, 11 (02):
  • [2] Immunologic response and memory T cells in subjects cured of tegumentary leishmaniasis
    Carvalho, Augusto M.
    Magalhaes, Andrea
    Carvalho, Lucas P.
    Bacellar, Olivia
    Scott, Phillip
    Carvalho, Edgar M.
    [J]. BMC INFECTIOUS DISEASES, 2013, 13
  • [3] Protective and pathologic immune responses in human tegumentary leishmaniasis
    Carvalho, Lucas P.
    Passos, Sara
    Schriefer, Albert
    Carvalho, Edgar M.
    [J]. FRONTIERS IN IMMUNOLOGY, 2012, 3
  • [4] The Nlrp3 inflammasome, IL-1β, and neutrophil recruitment are required for susceptibility to a nonhealing strain of Leishmania major in C57BL/6 mice
    Charmoy, Melanie
    Hurrell, Benjamin P.
    Romano, Audrey
    Lee, Sang Hun
    Ribeiro-Gomes, Flavia
    Riteau, Nicolas
    Mayer-Barber, Katrin
    Tacchini-Cottier, Fabienne
    Sacks, David L.
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 (04) : 897 - 911
  • [5] Disease Severity in Patients Infected with Leishmania mexicana Relates to IL-1β
    Fernandez-Figueroa, Edith A.
    Rangel-Escareno, Claudia
    Espinosa-Mateos, Valeria
    Carrillo-Sanchez, Karol
    Salaiza-Suazo, Norma
    Carrada-Figueroa, Georgina
    March-Mifsut, Santiago
    Becker, Ingeborg
    [J]. PLOS NEGLECTED TROPICAL DISEASES, 2012, 6 (05):
  • [6] IL-17 Mediates Immunopathology in the Absence of IL-10 Following Leishmania major Infection
    Gonzalez-Lombana, Claudia
    Gimblet, Ciara
    Bacellar, Olivia
    Oliveira, Walker W.
    Passos, Sara
    Carvalho, Lucas P.
    Goldschmidt, Michael
    Carvalho, Edgar M.
    Scott, Phillip
    [J]. PLOS PATHOGENS, 2013, 9 (03)
  • [7] Glyburide inhibits the Cryopyrin/Nalp3 inflammasome
    Lamkanfi, Mohamed
    Mueller, James L.
    Vitari, Alberto C.
    Misaghi, Shahram
    Fedorova, Anna
    Deshayes, Kurt
    Lee, Wyne P.
    Hoffman, Hal M.
    Dixit, Vishva M.
    [J]. JOURNAL OF CELL BIOLOGY, 2009, 187 (01) : 61 - 70
  • [8] Activation and regulation of the inflammasomes
    Latz, Eicke
    Xiao, T. Sam
    Stutz, Andrea
    [J]. NATURE REVIEWS IMMUNOLOGY, 2013, 13 (06) : 397 - 411
  • [9] Inflammasome-derived IL-1β production induces nitric oxide-mediated resistance to Leishmania
    Lima-Junior, Djalma S.
    Costa, Diego L.
    Carregaro, Vanessa
    Cunha, Larissa D.
    Silva, Alexandre L. N.
    Mineo, Tiago W. P.
    Gutierrez, Fredy R. S.
    Bellio, Maria
    Bortoluci, Karina R.
    Flavell, Richard A.
    Bozza, Marcelo T.
    Silva, Joao S.
    Zamboni, Dario S.
    [J]. NATURE MEDICINE, 2013, 19 (07) : 909 - +
  • [10] CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1β production
    Novais, Fernanda O.
    Carvalho, Augusto M.
    Clark, Megan L.
    Carvalho, Lucas P.
    Beiting, Daniel P.
    Brodsky, Igor E.
    Carvalho, Edgar M.
    Scott, Phillip
    [J]. PLOS PATHOGENS, 2017, 13 (02)
12