Epithelial-mesenchymal transition in ovarian cancer

被引：241
作者：
Vergara, Daniele [1 ]
Merlot, Benjamin [1 ]
Lucot, Jean-Philippe [1 ]
Collinet, Pierre [1 ]
Vinatier, Denis [1 ]
Fournier, Isabelle [1 ]
Salzet, Michel [1 ]
机构：
[1] Univ Sci & Technol Lille, Lab Neuroimmunol Annelides, CNFS FRE 2933, IFR 147, F-59655 Villeneuve Dascq, France
来源：
CANCER LETTERS | 2010年 / 291卷 / 01期
关键词：
Ovarian cancer; Epithelial mesenchymal transition; TGF-beta; EGF; HGF; ET-1; EPIDERMAL-GROWTH-FACTOR; E-CADHERIN EXPRESSION; INDUCED EPITHELIOMESENCHYMAL TRANSITION; MESSENGER-RNA EXPRESSION; II RECEPTOR EXPRESSION; TUMOR-CELL INVASION; IN-SITU ANALYSIS; P70; S6; KINASE; SURFACE EPITHELIUM; FACTOR-BETA;
D O I：
10.1016/j.canlet.2009.09.017
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ovarian cancer is a highly metastatic disease and the leading cause of death from gynecologic malignancy. Hence, and understanding of the molecular changes associated with ovarian cancer metastasis could lead to the identification of targets for novel therapeutic interventions. The conversion of an epithelial cell to a mesenchymal cell plays a key role both in the embryonic development and cancer invasion and metastasis. Cells undergoing epithelial-mesenchymal transition (EMT) lose their epithelial morphology, reorganize their cytoskeleton and acquire a motile phenotype through the up- and down-regulation of several molecules including tight and adherent junctions proteins and mesenchymal markers. EMT is believed to be governed by signals from the neoplastic microenvironment including a variety of cytokines and growth factors. In ovarian cancer EMT is induced by transforming growth factor-beta (TGF-beta), epidermal growth factor (EGF), hepatocyte growth factor (HGF) and endothelin-1 (ET-1). Alterations in these cellular pathways candidate them as useful target for ovarian cancer treatment. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：59 / 66
页数：8
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