Leisure-time physical activity, sedentary behavior, and risk of breast cancer: Results from the SUN ('Seguimiento Universidad De Navarra') project

被引：8

作者：

Sanchez-Bayona, R. ^{[1
,2
,3
]}

Gardeazabal, I. ^{[1
,4
]}

Romanos-Nanclares, A. ^{[1
,5
]}

Fernandez-Lazaro, C. I. ^{[1
,5
]}

Alvarez-Alvarez, I. ^{[1
]}

Ruiz-Canela, M. ^{[1
,5
,6
]}

Gea, A. ^{[1
,5
,6
]}

Martinez-Gonzalez, M. A. ^{[1
,5
,6
,7
]}

Santisteban, M. ^{[3
,5
]}

Toledo, E. ^{[1
,5
,6
]}

机构：

[1] Univ Navarra, Sch Med, Dept Prevent Med & Publ Hlth, C Irunlarrea 1, Pamplona 31008, Spain

[2] Hosp Univ 12 Octubre, Breast Canc Unit, Dept Clin Oncol, Madrid, Spain

[3] Clin Univ Navarra, Dept Clin Oncol, Pamplona, Spain

[4] Hosp Univ Marques Valdecilla, Dept Clin Oncol, Santander, Spain

[5] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain

[6] Ctr Invest Biomed Red Area Fisiol Obes & Nutr CIB, Madrid, Spain

[7] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

来源：

PREVENTIVE MEDICINE | 2021年 / 148卷

关键词：

Breast cancer; Physical activity; Sedentary behavior; Cohort; TELEVISION-VIEWING TIME; LIFE-STYLE; OBESITY; SURVIVAL;

D O I：

10.1016/j.ypmed.2021.106535

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Evidence is still limited on the influence of sedentary lifestyles on breast cancer (BC) risk. Also, prospective information on the combined effects of both sedentariness and leisure-time physical activity (LTPA) is scarce. We aimed to assess the association of higher sedentary behavior and LTPA (separately and in combination) with the risk of BC in a middle-aged cohort of university graduates. The SUN Project is a follow-up study initiated in 1999 with recruitment permanently open. Baseline assessments included a validated questionnaire on LTPA and sedentary habits. Subsequently, participants completed biennial follow-up questionnaires. Multivariable adjusted Cox models were used to estimate the hazard ratios (HR) for incident BC according to LTPA, TV-watching, the joint classification of both, and a combined 8-item multidimensional active lifestyle score. We included 10,812 women, with 11.8 years of median follow-up of. Among 115,802 women-years of follow-up, we confirmed 101 incident cases of BC. Women in the highest category of LTPA ( 2 points) group. There was no significant supra-multiplicative interaction between TV-watching and LTPA. Both low LTPA and TV-watching 2 h/d may substantially increase BC risk, independently of each other.

引用

页数：8