Leisure-time physical activity, sedentary behavior, and risk of breast cancer: Results from the SUN ('Seguimiento Universidad De Navarra') project

被引:8
作者
Sanchez-Bayona, R. [1 ,2 ,3 ]
Gardeazabal, I. [1 ,4 ]
Romanos-Nanclares, A. [1 ,5 ]
Fernandez-Lazaro, C. I. [1 ,5 ]
Alvarez-Alvarez, I. [1 ]
Ruiz-Canela, M. [1 ,5 ,6 ]
Gea, A. [1 ,5 ,6 ]
Martinez-Gonzalez, M. A. [1 ,5 ,6 ,7 ]
Santisteban, M. [3 ,5 ]
Toledo, E. [1 ,5 ,6 ]
机构
[1] Univ Navarra, Sch Med, Dept Prevent Med & Publ Hlth, C Irunlarrea 1, Pamplona 31008, Spain
[2] Hosp Univ 12 Octubre, Breast Canc Unit, Dept Clin Oncol, Madrid, Spain
[3] Clin Univ Navarra, Dept Clin Oncol, Pamplona, Spain
[4] Hosp Univ Marques Valdecilla, Dept Clin Oncol, Santander, Spain
[5] Navarra Inst Hlth Res, IdiSNA, Pamplona, Spain
[6] Ctr Invest Biomed Red Area Fisiol Obes & Nutr CIB, Madrid, Spain
[7] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA
关键词
Breast cancer; Physical activity; Sedentary behavior; Cohort; TELEVISION-VIEWING TIME; LIFE-STYLE; OBESITY; SURVIVAL;
D O I
10.1016/j.ypmed.2021.106535
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Evidence is still limited on the influence of sedentary lifestyles on breast cancer (BC) risk. Also, prospective information on the combined effects of both sedentariness and leisure-time physical activity (LTPA) is scarce. We aimed to assess the association of higher sedentary behavior and LTPA (separately and in combination) with the risk of BC in a middle-aged cohort of university graduates. The SUN Project is a follow-up study initiated in 1999 with recruitment permanently open. Baseline assessments included a validated questionnaire on LTPA and sedentary habits. Subsequently, participants completed biennial follow-up questionnaires. Multivariable adjusted Cox models were used to estimate the hazard ratios (HR) for incident BC according to LTPA, TV-watching, the joint classification of both, and a combined 8-item multidimensional active lifestyle score. We included 10,812 women, with 11.8 years of median follow-up of. Among 115,802 women-years of follow-up, we confirmed 101 incident cases of BC. Women in the highest category of LTPA ( 2 points) group. There was no significant supra-multiplicative interaction between TV-watching and LTPA. Both low LTPA and TV-watching 2 h/d may substantially increase BC risk, independently of each other.
引用
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页数:8
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