EFFECTIVE TREATMENT OF SEVERE BK VIRUS-ASSOCIATED HEMORRHAGIC CYSTITIS WITH LEFLUNOMIDE IN CHILDREN AFTER HEMATOPOIETIC STEM CELL TRANSPLANTATION

被引：14
作者：
Wu, Kang-Hsi [1 ,2 ]
Weng, Tefu [2 ]
Wu, Han-Ping [3 ]
Peng, Ching-Tien [1 ,2 ,4 ]
Sheu, Ji-Nan [5 ,6 ]
Chao, Yu-Hua [5 ,6 ]
机构：
[1] China Med Univ, Sch Chinese Med, Taichung, Taiwan
[2] China Med Univ Hosp, Dept Pediat, Taichung, Taiwan
[3] Buddhist Tzu Chi Gen Hosp, Dept Pediat, Taichung Branch, Taichung, Taiwan
[4] Asia Univ, Dept Biotechnol & Bioinformat, Taichung, Taiwan
[5] Chung Shan Med Univ, Dept Pediat, Taichung, Taiwan
[6] Chung Shan Med Univ, Sch Med, Taichung, Taiwan
来源：
PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2014年 / 33卷 / 11期
关键词：
BK virus; leflunomide; hemorrhagic cystitis; hematopoietic stem cell transplantation; pediatrics; POLYOMAVIRUS BK; RECIPIENTS; NEPHROPATHY; DISEASES; MSCS;
D O I：
10.1097/INF.0000000000000407
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Leflunomide, an immunosuppressant with antiviral activity, was used to treat 5 children with severe BK virus-associated hemorrhagic cystitis after hematopoietic stem cell transplantation. Without severe side effects, BK viral loads in blood and urine decreased significantly after leflunomide treatment. Compared with 7 historical controls, duration of BK virus-associated hemorrhagic cystitis was significantly shorter in patients receiving leflunomide therapy (P < 0.01).
引用
收藏
页码：1193 / 1195
页数：4
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