Synthesis and biological studies of 1-amino β-carbolines

被引:75
作者
Boursereau, Y
Coldham, I
机构
[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
[2] Univ Exeter, Dept Chem, Exeter EX4 4QD, Devon, England
关键词
beta-carboline; manzamine; anticancer; antimalarial;
D O I
10.1016/j.bmcl.2004.09.036
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A selection of 1-amino-substituted beta-carbolines have been prepared by amination of 1-chloro-beta-carboline as simple mimics of manzamine A and chloroquine and their intercalating ability, anticancer and antimalarial activity were studied. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:5841 / 5844
页数:4
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