Synthesis and biological studies of 1-amino β-carbolines

被引：75
|
作者：
Boursereau, Y
Coldham, I
机构：
[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England
[2] Univ Exeter, Dept Chem, Exeter EX4 4QD, Devon, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 23期
关键词：
beta-carboline; manzamine; anticancer; antimalarial;
D O I：
10.1016/j.bmcl.2004.09.036
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A selection of 1-amino-substituted beta-carbolines have been prepared by amination of 1-chloro-beta-carboline as simple mimics of manzamine A and chloroquine and their intercalating ability, anticancer and antimalarial activity were studied. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5841 / 5844
页数：4
相关论文
共 50 条
  • [1] Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted β-carbolines
    Ma, Chunming
    Cao, Rihui
    Shi, Buxi
    Zhou, Xiantai
    Ma, Qin
    Sun, Jie
    Guo, Liang
    Yi, Wei
    Chen, Zhiyong
    Song, Huacan
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 45 (11) : 5513 - 5519
  • [2] A NEW SYNTHESIS OF 1-AMINO AND 2-AMINO PHENAZINES
    GRAY, A
    GAERTNER, G
    HOLLIMAN, FG
    TETRAHEDRON LETTERS, 1959, (07) : 24 - 26
  • [3] SYNTHESIS OF SOME 1-AMINO ALICYCLIC CARBOXYLIC ACIDS AND THEIR DERIVATIVES
    CREMLYN, RJW
    ELLAM, RM
    MITRA, TK
    INDIAN JOURNAL OF CHEMISTRY, 1970, 8 (03): : 218 - &
  • [4] About 1-amino vinylether
    Klages, F
    Drerup, E
    JUSTUS LIEBIGS ANNALEN DER CHEMIE, 1941, 547 : 65 - 72
  • [5] Synthesis and biological evaluation of 1-amino isochromans from 2-bromoethyl benzaldehyde and amines in acid medium
    Fatima, Narjis
    Reddy, B. V. Subba
    Sabitha, Gowravaram
    Yadav, J. S.
    Sudhakar, Kadari
    Putta, Chandra Shekar
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (02) : 196 - 201
  • [6] SOME DERIVATIVES OF 1-AMINO ADAMANTANE
    TSATSAS, G
    COSTAKIS, E
    CASADIO, S
    LUMACHI, B
    MARRAZZI.E
    ANNALES PHARMACEUTIQUES FRANCAISES, 1969, 27 (05): : 363 - &
  • [7] SYNTHESIS OF ISOTOPICALLY LABELLED 1-AMINO ACID-1-DEOXY-2-KETOHEXOSES
    SPROTT, WE
    JOURNAL OF LABELLED COMPOUNDS, 1966, 2 (04): : 418 - &
  • [8] Synthesis, characterization and antimicrobial activity of some novel 1-amino dibenzofuran derivatives
    Shafi, S. Syed
    Subaash, R.
    Senthilkumar, S.
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2021, 60 (07): : 1022 - 1026
  • [9] ROLE OF THE 1-AMINO GROUP IN AMINOCYCLITOL ANTIBIOTICS - SYNTHESIS OF 1-DEAMINOGENTAMICIN-C2
    PHILIPPE, M
    QUICLETSIRE, B
    SEPULCHRE, AM
    GERO, SD
    LOIBNER, H
    STREICHER, W
    STUTZ, P
    MOREAU, N
    JOURNAL OF ANTIBIOTICS, 1983, 36 (03): : 250 - 255
  • [10] γ-Carbolines and their hydrogenated derivatives. 1. Aromatic γ-carbolines: methods of synthesis, chemical and biological properties (review)
    R. S. Alekseyev
    A. V. Kurkin
    M. A. Yurovskaya
    Chemistry of Heterocyclic Compounds, 2009, 45 : 889 - 925
12345