Control of mRNA stability and translation during Drosophila development

被引：23

作者：

Cooperstock, RL

Lipshitz, HD

机构：

[1] Hosp Sick Children, Program Dev Biol, Res Inst, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Dept Mol & Med Genet, Toronto, ON, Canada

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 1997年 / 8卷 / 06期

基金：

英国医学研究理事会;

关键词：

cytoplasmic polyadenylation; deadenylation; RNA degradation; translational repression;

D O I：

10.1006/scdb.1997.0179

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Translational control of mRNAs regulates the spatiotemporal production of the proteins they encode. Further refinement of mRNA and protein distribution patterns is brought about by regulation of transcript stability. Genetic and molecular analyses in Drosophila can provide unparalleled insight into the developmental functions of the modulation of mRNA translation and stability. These mechanisms play a key rob in regulating the production of cell fate determinants, cell cycle regulators and molecular chaperones. (C) 1997 Academic Press Ltd.

引用

页码：541 / 549

页数：9

共 59 条

[1]

AKAM M, 1987, DEVELOPMENT, V101, P1

[2] THE ROLE OF LOCALIZATION OF BICOID RNA IN ORGANIZING THE ANTERIOR PATTERN OF THE DROSOPHILA EMBRYO [J].