New insights in adrenal Cushing syndrome

被引：1

作者：

Haissaguerre, M. ^{[1
]}

Tabarin, A. ^{[1
]}

机构：

[1] Hop Haut Leveque, CHU Bordeaux, Fac Med Bordeaux Victor Segalen, Serv Endocrinol Diabetol & Malad Metabol, F-33600 Pessac, France

来源：

ANNALES D ENDOCRINOLOGIE | 2014年 / 75卷

关键词：

ACTH-independent Cushing's syndrome; Bilateral Macronodular Adrenal Hyperplasia (AIMAH); ARMC5; mutations; PRKACA mutations; Subclinical Cortisol-Secreting Adenomas; ARMC5; MUTATIONS; CORTISOL SECRETION; GENE-EXPRESSION; HYPERPLASIA; VASOPRESSIN; CORTICOTROPIN; INCIDENTALOMA; RECEPTORS; PRKACA;

D O I：

10.1016/S0003-4266(14)70025-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The development of molecular biology tools has allowed major advances in the genetic determinism and the pathophysiology of pheochromocytomas and Conn's adenomas. However, the molecular pathophysiology of ACTH-independent Cushing's Syndrome was mostly unknown until recently. In 2014, major new insights concerning the physiopathology of ACTH-independent macronodular adrenal hyperplasias (AIMAH) and the cortisol-secreting adenomas have been published. Elsewhere, the cardiovascular consequences of the subclinical hypercortisolism due to adrenal incidentalomas, was described only in some cross-sectional studies. The natural history of these lesions has been documented in two large follow-up studies. These new data presented during the Endocrine Congress are summarized herein. (C) 2014 Published by Elsevier Masson SAS. All rights reserved.

引用

页码：S37 / S45

页数：9

共 37 条

[1] ARMC5 Mutations Are a Frequent Cause of Primary Macronodular Adrenal Hyperplasia [J].

Alencar, Guilherme Asmar ;

Lerario, Antonio Marcondes ;

Nishi, Mirian Yumie ;

de Paula Mariani, Beatriz Marinho ;

Almeida, Madson Queiroz ;

Tremblay, Johanne ;

Hamet, Pavel ;

Bourdeau, Isabelle ;

Nogueira Zerbini, Maria Claudia ;

Albergaria Pereira, Maria Adelaide ;

Gomes, Gilberto Carlos ;

Rocha, Manoel de Souza ;

Chambo, Jose Luis ;

Lacroix, Andre ;

Mendonca, Berenice Bilharinho ;

Barisson Villares Fragoso, Maria Candida .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 99 (08) :E1501-E1509

[2] Integrated Genomic Analysis of Nodular Tissue in Macronodular Adrenocortical Hyperplasia: Progression of Tumorigenesis in a Disorder Associated with Multiple Benign Lesions [J].

Almeida, Madson Q. ;

Harran, Michelle ;

Bimpaki, Eirini I. ;

Hsiao, Hui-Pin ;

Horvath, Anelia ;

Cheadle, Chris ;

Watkins, Tonya ;

Nesterova, Maria ;

Stratakis, Constantine A. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (04) :E728-E738

[3] How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues? [J].

Almeida, Madson Q. ;

Stratakis, Constantine A. .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2011, 336 (1-2) :162-168

[4] ARMC5 Mutations in Macronodular Adrenal Hyperplasia with Cushing's Syndrome [J].

Assie, Guillaume ;

Libe, Rossella ;

Espiard, Stephanie ;

Rizk-Rabin, Marthe ;

Guimier, Anne ;

Luscap, Windy ;

Barreau, Olivia ;

Lefevre, Lucile ;

Sibony, Mathilde ;

Guignat, Laurence ;

Rodriguez, Stephanie ;

Perlemoine, Karine ;

Rene-Corail, Fernande ;

Letourneur, Franck ;

Trabulsi, Bilal ;

Poussier, Alix ;

Chabbert-Buffet, Nathalie ;

Borson-Chazot, Francoise ;

Groussin, Lionel ;

Bertagna, Xavier ;

Stratakis, Constantine A. ;

Ragazzon, Bruno ;

Bertherat, Jerome .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (22) :2105-2114

[5] In vivo and in vitro screening for illegitimate receptors in adrenocorticotropin-independent macronodular adrenal hyperplasia causing Cushing's syndrome:: Identification of two cases of gonadotropin/gastric inhibitory polypeptide-dependent hypercortisolism [J].

Bertherat, J ;

Contesse, V ;

Louiset, E ;

Barrande, G ;

Duparc, C ;

Groussin, L ;

Émy, P ;

Bertagna, X ;

Kuhn, JM ;

Vaudry, H ;

Lefebvre, H .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (03) :1302-1310

[6] Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome [J].

Beuschlein, Felix ;

Fassnacht, Martin ;

Assie, Guillaume ;

Calebiro, Davide ;

Stratakis, Constantine A. ;

Osswald, Andrea ;

Ronchi, Cristina L. ;

Wieland, Thomas ;

Sbiera, Silviu ;

Faucz, Fabio R. ;

Schaak, Katrin ;

Schmittfull, Anett ;

Schwarzmayr, Thomas ;

Barreau, Olivia ;

Vezzosi, Delphine ;

Rizk-Rabin, Marthe ;

Zabel, Ulrike ;

Szarek, Eva ;

Salpea, Paraskevi ;

Forlino, Antonella ;

Vetro, Annalisa ;

Zuffardi, Orsetta ;

Kisker, Caroline ;

Diener, Susanne ;

Meitinger, Thomas ;

Lohse, Martin J. ;

Reincke, Martin ;

Bertherat, Jerome ;

Strom, Tim M. ;

Allolio, Bruno .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (11) :1019-1028

[7] Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome [J].

Cao, Yanan ;

He, Minghui ;

Gao, Zhibo ;

Peng, Ying ;

Li, Yanli ;

Li, Lin ;

Zhou, Weiwei ;

Li, Xiangchun ;

Zhong, Xu ;

Lei, Yiming ;

Su, Tingwei ;

Wang, Hang ;

Jiang, Yiran ;

Yang, Lin ;

Wei, Wei ;

Yang, Xu ;

Jiang, Xiuli ;

Liu, Li ;

He, Juan ;

Ye, Junna ;

Wei, Qing ;

Li, Yingrui ;

Wang, Weiqing ;

Wang, Jun ;

Ning, Guang .

SCIENCE, 2014, 344 (6186) :913-917

[8] Visceral Fat Accumulation and Postdexamethasone Serum Cortisol Levels in Patients With Adrenal Incidentaloma [J].

Debono, Miguel ;

Prema, Anna ;

Hughes, Timothy J. B. ;

Bull, Matthew ;

Ross, Richard J. ;

Newell-Price, John .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2013, 98 (06) :2383-2391

[9]

Di Dalmazi G, 2014, J CLIN ENDOCR METAB

[10] Cardiovascular events and mortality in patients with adrenal incidentalomas that are either non-secreting or associated with intermediate phenotype or subclinical Cushing's syndrome: a 15-year retrospective study [J].

Di Dalmazi, Guido ;

Vicennati, Valentina ;

Garelli, Silvia ;

Casadio, Elena ;

Rinaldi, Eleonora ;

Giampalma, Emanuela ;

Mosconi, Cristina ;

Golfieri, Rita ;

Paccapelo, Alexandro ;

Pagotto, Uberto ;

Pasquali, Renato .

LANCET DIABETES & ENDOCRINOLOGY, 2014, 2 (05) :396-405

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