Total synthesis of graphislactone G

被引：21

作者：

Cudaj, Judith ^{[1
]}

Podlech, Joachim ^{[1
]}

机构：

[1] KIT, Inst Organ Chem, D-76131 Karlsruhe, Germany

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 23期

关键词：

Polyketides; Fungal metabolites; Resorcylic lactones; Cross Coupling; Suzuki reaction; ENDOPHYTIC FUNGUS; METABOLITES; BIOSYNTHESIS; DERIVATIVES; MYCOBIONTS;

D O I：

10.1016/j.tetlet.2010.04.024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We present a total synthesis of the fungal natural product graphislactone G, a chlorinated resorcylic lactone. The key step is a Suzuki coupling used for the construction of the central biaryl bond. Graphislactone G was prepared in 13 steps with 22% yield starting with orcinol and phloroglucinic acid, where the longest linear sequence consists of nine steps. (C) 2010 Elsevier Ltd. All rights reserved.

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页码：3092 / 3094

页数：3

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