New acetylated flavone C-glycosides from Iris lactea

被引：8
|
作者：
Whaley, Andrei K. [1 ,2 ]
Ebrahim, Weaam [1 ,3 ]
El-Neketi, Mona [3 ]
Ancheeva, Elena U. [1 ,2 ]
Ozkaya, Ferhat Can [1 ]
Pryakhina, Nina I. [2 ]
Sipkina, Nadezhda U. [2 ]
Luzhanin, Vladimir G. [2 ]
Liu, Zhen [1 ]
Proksch, Peter [1 ]
机构：
[1] Heinrich Heine Univ Dusseldorf, Inst Pharmaceut Biol & Biotechnol, Univ Str 1, D-40225 Dusseldorf, Germany
[2] St Petersburg State Chem Pharmaceut Acad, St Prof Popova 14, St Petersburg 197376, Russia
[3] Mansoura Univ, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 22期
关键词：
Flavone C-glycosides; Rotamers; Iris lactea; GLYCOSYLFLAVONES; LEAVES;
D O I：
10.1016/j.tetlet.2017.04.080
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Chemical investigation of the aerial parts of Iris lactea afforded three new flavone C-glycosides including 4'''-O-acetyl-embinin (1), 2''',4"'-O-diacetyl-embinin (2) and 6 '',4"'-O-diacetyl-embinin (3) along with the known analogue embinin (4). Their structures were elucidated by 1D and 2D NMR spectroscopic analysis as well as by HRESIMS data. The sugars were characterized following acid hydrolysis of the respective glycosides and TLC analysis compared to known standards. Duplicated signals can be observed in the NMR spectra, indicating the presence of rotamers caused by rotational hindrance around the glycosyl-flavone C-C linkage. All isolated compounds were tested for their antimicrobial and cytotoxic activities but found to be inactive. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2171 / 2173
页数：3
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