From Plasminogen to Plasmin: Role of Plasminogen Receptors in Human Cancer

被引：60
作者：
Didiasova, Miroslava [1 ]
Wujak, Lukasz [1 ]
Wygrecka, Malgorzata [1 ,2 ]
Zakrzewicz, Dariusz [1 ]
机构：
[1] Univ Giessen, Dept Biochem, Fac Med, Lung Ctr, D-35392 Giessen, Germany
[2] German Ctr Lung Res, D-35392 Giessen, Germany
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 11期
关键词：
actin; annexin; 2; cytokeratin-8; enolase-1; plasmin; plasminogen; plasminogen receptor; CELL LUNG-CANCER; ANNEXIN A2 HETEROTETRAMER; ALPHA-ENOLASE; BREAST-CANCER; TUMOR-GROWTH; BETA-ACTIN; PANCREATIC-CANCER; CARCINOMA-CELLS; CYTOKERATIN; GLYCOLYTIC-ENZYMES;
D O I：
10.3390/ijms151121229
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cell surface-associated proteolysis mediated by plasmin (PLA) is an essential feature of wound healing, angiogenesis and cell invasion, processes that are dysregulated in cancer development, progression and systemic spread. The generation of PLA, initiated by the binding of its precursor plasminogen (PLG) to the cell surface, is regulated by an array of activators, inhibitors and receptors. In this review, we will highlight the importance of the best-characterized components of the PLG/PLA cascade in the pathogenesis of cancer focusing on the role of the cell surface-PLG receptors (PLG-R). PLG-R overexpression has been associated with poor prognosis of cancer patients and resistance to chemotherapy. We will also discuss recent findings on the molecular mechanisms regulating cell surface expression and distribution of PLG-R.
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页码：21229 / 21252
页数：24
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