From Plasminogen to Plasmin: Role of Plasminogen Receptors in Human Cancer

被引:56
|
作者
Didiasova, Miroslava [1 ]
Wujak, Lukasz [1 ]
Wygrecka, Malgorzata [1 ,2 ]
Zakrzewicz, Dariusz [1 ]
机构
[1] Univ Giessen, Dept Biochem, Fac Med, Lung Ctr, D-35392 Giessen, Germany
[2] German Ctr Lung Res, D-35392 Giessen, Germany
关键词
actin; annexin; 2; cytokeratin-8; enolase-1; plasmin; plasminogen; plasminogen receptor; CELL LUNG-CANCER; ANNEXIN A2 HETEROTETRAMER; ALPHA-ENOLASE; BREAST-CANCER; TUMOR-GROWTH; BETA-ACTIN; PANCREATIC-CANCER; CARCINOMA-CELLS; CYTOKERATIN; GLYCOLYTIC-ENZYMES;
D O I
10.3390/ijms151121229
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cell surface-associated proteolysis mediated by plasmin (PLA) is an essential feature of wound healing, angiogenesis and cell invasion, processes that are dysregulated in cancer development, progression and systemic spread. The generation of PLA, initiated by the binding of its precursor plasminogen (PLG) to the cell surface, is regulated by an array of activators, inhibitors and receptors. In this review, we will highlight the importance of the best-characterized components of the PLG/PLA cascade in the pathogenesis of cancer focusing on the role of the cell surface-PLG receptors (PLG-R). PLG-R overexpression has been associated with poor prognosis of cancer patients and resistance to chemotherapy. We will also discuss recent findings on the molecular mechanisms regulating cell surface expression and distribution of PLG-R.
引用
收藏
页码:21229 / 21252
页数:24
相关论文
共 50 条
  • [1] The plasmin/plasminogen system and cancer
    Martin, P. -M.
    Dussert, C.
    Romain, S.
    Ouafik, L. H.
    ONCOLOGIE, 2010, 12 (5-6) : 322 - 340
  • [2] Characterization of plasmin, plasminogen and plasminogen activator in goat milk
    Fantuz, F.
    Polidori, P.
    Lebboroni, G.
    Polidori, F.
    ITALIAN JOURNAL OF ANIMAL SCIENCE, 2003, 2 : 554 - 556
  • [3] Enzymatic assays for native plasmin, plasminogen and plasminogen activators in bovine milk
    Saint-Denis, T
    Humbert, G
    Gaillard, JL
    JOURNAL OF DAIRY RESEARCH, 2001, 68 (03) : 437 - 449
  • [4] Elevated levels of urine angiostatin and plasminogen/plasmin in cancer patients
    Cao, YH
    Veitonmäki, N
    Keough, K
    Cheng, H
    Lee, LS
    Cao, YM
    Zurakowski, D
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2000, 5 (05) : 547 - 551
  • [5] Plasmin and Plasminogen System in the Tumor Microenvironment: Implications for Cancer Diagnosis, Prognosis, and Therapy
    Bharadwaj, Alamelu G.
    Holloway, Ryan W.
    Miller, Victoria A.
    Waisman, David M.
    CANCERS, 2021, 13 (08)
  • [6] STREPTOKINASE-PLASMIN COMPLEX BINDS TO PLASMINOGEN RECEPTORS ON RAT HEPATOCYTES AND HUMAN ENDOTHELIUM
    HUMPHRIES, JE
    HALL, SW
    VANDENBERG, SR
    GONIAS, SL
    FIBRINOLYSIS, 1991, 5 (03) : 171 - 176
  • [7] Structure and function of plasminogen/plasmin system
    R. B. Aisina
    L. I. Mukhametova
    Russian Journal of Bioorganic Chemistry, 2014, 40 : 590 - 605
  • [8] Plasminogen and plasmin in Alzheimer's disease
    Barker, Rachel
    Love, Seth
    Kehoe, Patrick G.
    BRAIN RESEARCH, 2010, 1355 : 7 - 15
  • [9] The interaction of Streptococcus dysgalactiae with plasmin and plasminogen
    Leigh, JA
    Hodgkinson, SM
    Lincoln, RA
    VETERINARY MICROBIOLOGY, 1998, 61 (1-2) : 121 - 135
  • [10] Structure and Function of Plasminogen/Plasmin System
    Aisina, R. B.
    Mukhametova, L. I.
    RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY, 2014, 40 (06) : 590 - 605