Organocatalytic Asymmetric Decarboxylative Addition of -Ketoacids to Methyleneindolinones Derivatives

被引：6

作者：

Kumari, Anita ^{[1
]}

Kaur, Jasneet ^{[1
]}

Bhardwaj, Vimal K. ^{[2
]}

Chimni, Swapandeep Singh ^{[1
]}

机构：

[1] Guru Nanak Dev Univ, Dept Chem, UGC Ctr Advance Studies Chem, Amritsar 143005, Punjab, India

[2] Indian Inst Technol Ropar, Dept Chem, Nangal Rd, Rupnagar 140001, India

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 30期

关键词：

Methyleneindolinones; -Keto acids; Decarboxylation; Organocatalyst; Enantioselective; ACID HALF-THIOESTERS; ENANTIOSELECTIVE CONJUGATE ADDITION; POLYKETIDE SYNTHASES; ALDOL REACTIONS; 1,3-DICARBONYL COMPOUNDS; SQUARAMIDE DERIVATIVES; MICHAEL-ADDITION; BIOSYNTHESIS; ALPHA; ALDEHYDES;

D O I：

10.1002/ejoc.201800454

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The quinine squaramide-catalyzed enantioselective decarboxylative addition reaction of various -keto acids with methyleneindolinones has been developed. Through this methodology, various oxindole derivatives were synthesized in good yields (up to 93%) and excellent enantiomeric excess (up to 99% ee) and moderate diastereoselectivity (up to 66:34).

引用

页码：4081 / 4088

页数：8

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