Organocatalytic Asymmetric Decarboxylative Addition of -Ketoacids to Methyleneindolinones Derivatives

被引：6
|
作者：
Kumari, Anita [1 ]
Kaur, Jasneet [1 ]
Bhardwaj, Vimal K. [2 ]
Chimni, Swapandeep Singh [1 ]
机构：
[1] Guru Nanak Dev Univ, Dept Chem, UGC Ctr Advance Studies Chem, Amritsar 143005, Punjab, India
[2] Indian Inst Technol Ropar, Dept Chem, Nangal Rd, Rupnagar 140001, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 30期
关键词：
Methyleneindolinones; -Keto acids; Decarboxylation; Organocatalyst; Enantioselective; ACID HALF-THIOESTERS; ENANTIOSELECTIVE CONJUGATE ADDITION; POLYKETIDE SYNTHASES; ALDOL REACTIONS; 1,3-DICARBONYL COMPOUNDS; SQUARAMIDE DERIVATIVES; MICHAEL-ADDITION; BIOSYNTHESIS; ALPHA; ALDEHYDES;
D O I：
10.1002/ejoc.201800454
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The quinine squaramide-catalyzed enantioselective decarboxylative addition reaction of various -keto acids with methyleneindolinones has been developed. Through this methodology, various oxindole derivatives were synthesized in good yields (up to 93%) and excellent enantiomeric excess (up to 99% ee) and moderate diastereoselectivity (up to 66:34).
引用
收藏
页码：4081 / 4088
页数：8
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