Synthesis and structure-activity studies of antofine analogues as potential anticancer agents

被引：93

作者：

Fu, Ye

Lee, Sang Kook

Min, Hye-Young

Lee, Taeho

Lee, Jaekwang

Cheng, Maosheng

Kim, Sanghee

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

[2] Seoul Natl Univ, Coll Pharm, Inst Nat Prod Res, Seoul 110460, South Korea

[3] Ewha Womans Univ, Coll Pharm, Seoul 120750, South Korea

[4] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 01期

关键词：

antofine; phenanthroindolizidine; structure-activity relationship; anticancer;

D O I：

10.1016/j.bmcl.2006.09.080

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Due to the profound cytotoxicities and interesting biochemical aspects, phenanthroindolizidine alkaloids have received an attention as potential therapeutic leads. To define the features of the molecule that are essential for cytotoxicity, we have synthesized and evaluated a series of phenanthroindolizidine alkaloid, antofine, analogues with different substituents on the phenanthrene ring. The systematic structure activity relationship studies elucidate the essential functional group requirement of phenanthrene ring, providing the basis for further development of phenanthroindolizidine alkaloids. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：97 / 100

页数：4

共 34 条

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