Radical Esterification of Unactivated Alkenes Using Formate asCarbonyl Source

被引：7

作者：

Mu, Bing ^{[1
,2
,3
,4
]}

Xia, Shiwei ^{[5
]}

Wu, Linna ^{[5
]}

Li, Jingya ^{[6
]}

Li, Zhongxian ^{[7
]}

Wang, Zechao ^{[5
]}

Wu, Junliang ^{[1
,2
]}

机构：

[1] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China

[2] Zhengzhou Univ, Inst Green Catalysis, Zhengzhou 450001, Peoples R China

[3] Huzhou Univ, Coll Life Sci, Huzhou 313000, Zhejiang, Peoples R China

[4] Zhengzhou Normal Univ, Coll Chem & Chem Engn, Zhengzhou 450044, Peoples R China

[5] Zhengzhou Univ, Henan Inst Adv Technol, Div Mol Catalysis & Synth, Zhengzhou 450001, Peoples R China

[6] Leadmedpharm Co Ltd, Huzhou 313100, Zhejiang, Peoples R China

[7] Henan Acad Sci, High & New Technol Res Ctr, Zhengzhou 450002, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 07期

基金：

中国国家自然科学基金;

关键词：

PALLADIUM-CATALYZED CARBONYLATION; METHYL FORMATE; ARYL OLEFINS; FORMIC-ACID; HYDROESTERIFICATION; DIHYDROISOQUINOLINONES; ALKOXYCARBONYLATION; DERIVATIVES; EFFICIENT; ALKYNES;

D O I：

10.1021/acs.joc.1c02808

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In recent years, methyl formate has receivedconsiderable attention as an ideal and green C1 building blockto synthesize carboxylic esters. However, examples of a one-steproute to esters with one-carbon elongation using methyl formate asa source of methoxycarbonyl radical are still rare. Herein, wepresent peroxide-induced radical carbonylation ofN-(2-methylallyl)benzamides with methyl formate as the precursor ofmethoxycarbonyl radical and RuCl3as catalyst, affording a series ofbiologically valuable 4-[(methoxycarbonyl)methyl]-3,4-dihydroiso-quinolinones with good tolerance and insensitivity to moisture inone pot under simple and mild conditions.

引用

页码：4918 / 4925

页数：8

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