A model system for analyzing somatic mutations in Drosophila melanogaster

被引：21

作者：

Garcia, Ana Maria

Derventzi, Anastasia

Busuttil, Rita

Calder, R. Brent

Perez, Ernesto, Jr.

Chadwell, Linda

Dolle, Martijn E. T.

Lundell, Martha

Vijg, Jan

机构：

[1] Buck Inst Age Res, Novato, CA 94945 USA

[2] Univ Texas San Antonio, San Antonio, TX 78249 USA

[3] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 USA

[4] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

来源：

NATURE METHODS | 2007年 / 4卷 / 05期

关键词：

D O I：

10.1038/NMETH1027

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Presently there are no good assays for comparing somatic mutation frequencies and spectra between different vertebrate and invertebrate organisms. Here we describe a new lacZ mutation reporter system in D. melanogaster, which complements existing systems in the mouse. The results obtained with the new model indicate two- to threefold higher frequencies of spontaneous mutations than in the mouse, with most of the mutations characterized as large genome rearrangements.

引用

收藏

页码：401 / 403

页数：3

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