Differential binding patterns to host cells associated with particles of several human alphapapillomavirus types

被引：15
作者：
Broutian, Tatevik R. [1 ,2 ,3 ]
Brendle, Sarah A. [1 ,2 ]
Christensen, Neil D. [1 ,2 ,3 ]
机构：
[1] Penn State Univ, Coll Med, Jake Gittlen Canc Res Fdn, Hershey, PA 17033 USA
[2] Penn State Univ, Coll Med, Dept Pathol, Hershey, PA 17033 USA
[3] Penn State Univ, Coll Med, Dept Microbiol & Immunol, Hershey, PA 17033 USA
来源：
JOURNAL OF GENERAL VIROLOGY | 2010年 / 91卷
基金：
美国国家卫生研究院;
关键词：
VIRUS-LIKE PARTICLES; SURFACE HEPARAN-SULFATE; HUMAN-PAPILLOMAVIRUS; MONOCLONAL-ANTIBODIES; EXTRACELLULAR-MATRIX; HUMAN KERATINOCYTES; INFECTION; INHIBITION; REACTIVITY; RECEPTORS;
D O I：
10.1099/vir.0.012732-0
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The focus of this research was to compare the binding profiles of human papillomavirus (HPV) 11, 16, 18 and 45 virus-like particles (VLPs) to HaCaT cells and to the extracellular matrix (ECM) secreted by these cells. All four HPV types tested bind to a component(s) of the ECM. HPV11 VLP binding is blocked when the ECM is pretreated with an anti-laminin 5 (LN5) polyclonal antibody. A series of treatments utilizing heparins and heparinase revealed that HPV18 VLPs are dependent on heparan sulfates (HS) for binding to cells and ECM. HPV16 and HPV45 VLPs are dependent on HS for binding to HaCaT cells and dependent on both HIS and LN5 for binding to ECM. These studies emphasize the need to study the binding characteristics of different HPV types before applying universal binding principles to all papillomaviruses.
引用
收藏
页码：531 / 540
页数：10
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