Association of pelvic inflammatory disease (PID) with ectopic pregnancy and preterm labor in Taiwan: A nationwide population-based retrospective cohort study

被引:23
作者
Huang, Chun-Chung [1 ]
Huang, Chien-Chu [2 ,3 ]
Lin, Shao-Yi [4 ]
Chang, Cherry Yin-Yi [2 ,5 ]
Lin, Wu-Chou [2 ,5 ]
Chung, Chi-Hsiang [6 ]
Lin, Fu-Huang [6 ]
Tsao, Chang-Huei [7 ,8 ]
Lo, Chun-Min [1 ]
Chien, Wu-Chien [6 ,7 ,9 ]
机构
[1] Natl Yang Ming Univ, Dept Biomed Engn, Taipei, Taiwan
[2] China Med Univ Hosp, Dept Obstet & Gynecol, Taichung, Taiwan
[3] China Med Univ, Grad Inst Biomed Sci, Taichung, Taiwan
[4] Natl Formosa Univ, Dept Mech & Comp Aided Engn, Huwei Township, Yunlin, Taiwan
[5] China Med Univ, Dept Med, Taichung, Taiwan
[6] Natl Def Med Ctr, Sch Publ Hlth, Taipei, Taiwan
[7] Triserv Gen Hosp, Dept Med Res, Taipei, Taiwan
[8] Natl Def Med Ctr, Dept Microbiol & Immunol, Taipei, Taiwan
[9] Natl Def Med Ctr, Grad Inst Life Sci, Taipei, Taiwan
来源
PLOS ONE | 2019年 / 14卷 / 08期
关键词
CHLAMYDIA-TRACHOMATIS; BACTERIAL VAGINOSIS; SEXUAL-BEHAVIOR; SEQUELAE; INFECTION; DIAGNOSIS; EPIDEMIOLOGY; ENDOMETRITIS; SALPINGITIS; PREVALENCE;
D O I
10.1371/journal.pone.0219351
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Pelvic inflammatory disease (PID) is an infectious disease that causes tubal occlusion and other pelvic and abdominal adhesions. The incidence of pelvic inflammatory disease (PID) has increased due to the sexually active status of the young population. This leads to a more serious problem and a larger effect than previously observed. However, there have been few studies on this topic in Asian populations. Aim We aimed to evaluate the risk of preterm labor and/or ectopic pregnancy in Taiwanese women following PID. Design Using the Taiwan National Health Insurance Database, we designed a retrospective cohort study that included 12-to 55-year-old pregnant women between 2000 and 2010. We selected a 1: 3 age-matched control group of non-PID women. The endpoint was any episode of preterm labor or ectopic pregnancy; otherwise, the patients were tracked until 31 December 2010. Methods The risk factors for preterm labor or ectopic pregnancy were explored. For cases included from the index date until the end of 2010, we analyzed the risk of incident preterm labor or ectopic pregnancy. With the use of a multivariate Cox proportional hazard regression analysis, we calculated the hazard ratio (HR) with a 95% CI and compared it with that of the control group. Results This study examined 30,450 patients with PID and 91,350 controls. During the follow-up period, patients in the PID group were more likely to develop preterm labor or ectopic pregnancy than patients in the control group. The cumulative incidence rates for developing preterm labor were 1.84% (561/30,450 individuals) in patients with PID and 1.63% (1492/91,350 individuals) in patients without PID. On the other hand, the cumulative incidence rate for developing ectopic pregnancy in patients with PID was 0.05% (14/30,450 individuals) but was only 0.04% (33/91,350 individuals) in patients without PID. Compared with those without PID, the patients with PID had a 1.864 times (P< 0.001) higher risk of developing preterm labor and a 2.121 times (P = 0.003) higher risk of developing ectopic pregnancy. Conclusion Our study provided evidence of an increased risk of preterm labor or ectopic pregnancy in PID patients.
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页数:13
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